Anti-Remodeling Effects of Rapamycin in Experimental Heart Failure: Dose Response and Interaction with Angiotensin Receptor Blockade

While neurohumoral antagonists improve outcomes in heart failure (HF), cardiac remodeling and dysfunction progress and outcomes remain poor. Therapies superior or additive to standard HF therapy are needed. Pharmacologic mTOR inhibition by rapamycin attenuated adverse cardiac remodeling and dysfunct...

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Detalles Bibliográficos
Autores principales: Bishu, Kalkidan, Ogut, Ozgur, Kushwaha, Sudhir, Mohammed, Selma F., Ohtani, Tomohito, Xu, Xiaolei, Brozovich, Frank V., Redfield, Margaret M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849273/
https://www.ncbi.nlm.nih.gov/pubmed/24312548
http://dx.doi.org/10.1371/journal.pone.0081325

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