A physiologically-based flow network model for hepatic drug elimination I: regular lattice lobule model

We develop a physiologically-based lattice model for the transport and metabolism of drugs in the functional unit of the liver, called the lobule. In contrast to earlier studies, we have emphasized the dominant role of convection in well-vascularized tissue with a given structure. Estimates of conve...

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Detalles Bibliográficos
Autores principales: Rezania, Vahid, Marsh, Rebeccah, Coombe, Dennis, Tuszynski, Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849449/
https://www.ncbi.nlm.nih.gov/pubmed/24007328
http://dx.doi.org/10.1186/1742-4682-10-52
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author Rezania, Vahid
Marsh, Rebeccah
Coombe, Dennis
Tuszynski, Jack
author_facet Rezania, Vahid
Marsh, Rebeccah
Coombe, Dennis
Tuszynski, Jack
author_sort Rezania, Vahid
collection PubMed
description We develop a physiologically-based lattice model for the transport and metabolism of drugs in the functional unit of the liver, called the lobule. In contrast to earlier studies, we have emphasized the dominant role of convection in well-vascularized tissue with a given structure. Estimates of convective, diffusive and reaction contributions are given. We have compared drug concentration levels observed exiting the lobule with their predicted detailed distribution inside the lobule, assuming that most often the former is accessible information while the latter is not.
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spelling pubmed-38494492013-12-06 A physiologically-based flow network model for hepatic drug elimination I: regular lattice lobule model Rezania, Vahid Marsh, Rebeccah Coombe, Dennis Tuszynski, Jack Theor Biol Med Model Research We develop a physiologically-based lattice model for the transport and metabolism of drugs in the functional unit of the liver, called the lobule. In contrast to earlier studies, we have emphasized the dominant role of convection in well-vascularized tissue with a given structure. Estimates of convective, diffusive and reaction contributions are given. We have compared drug concentration levels observed exiting the lobule with their predicted detailed distribution inside the lobule, assuming that most often the former is accessible information while the latter is not. BioMed Central 2013-09-05 /pmc/articles/PMC3849449/ /pubmed/24007328 http://dx.doi.org/10.1186/1742-4682-10-52 Text en Copyright © 2013 Rezania et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Rezania, Vahid
Marsh, Rebeccah
Coombe, Dennis
Tuszynski, Jack
A physiologically-based flow network model for hepatic drug elimination I: regular lattice lobule model
title A physiologically-based flow network model for hepatic drug elimination I: regular lattice lobule model
title_full A physiologically-based flow network model for hepatic drug elimination I: regular lattice lobule model
title_fullStr A physiologically-based flow network model for hepatic drug elimination I: regular lattice lobule model
title_full_unstemmed A physiologically-based flow network model for hepatic drug elimination I: regular lattice lobule model
title_short A physiologically-based flow network model for hepatic drug elimination I: regular lattice lobule model
title_sort physiologically-based flow network model for hepatic drug elimination i: regular lattice lobule model
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849449/
https://www.ncbi.nlm.nih.gov/pubmed/24007328
http://dx.doi.org/10.1186/1742-4682-10-52
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