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Optimization of the piggyBac Transposon Using mRNA and Insulators: Toward a More Reliable Gene Delivery System
Integrating and expressing stably a transgene into the cellular genome remain major challenges for gene-based therapies and for bioproduction purposes. While transposon vectors mediate efficient transgene integration, expression may be limited by epigenetic silencing, and persistent transposase expr...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849487/ https://www.ncbi.nlm.nih.gov/pubmed/24312663 http://dx.doi.org/10.1371/journal.pone.0082559 |