Deciphering the role of natural variation in age-related protein homeostasis

Understanding the genetic basis of age-related diseases is a critical step toward developing therapies that promote healthy aging. Numerous genes have been identified that modulate lifespan, but the influence of natural variation in aging has not been well studied. A new report utilizing a transgeni...

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Detalles Bibliográficos
Autor principal: Kaeberlein, Matt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849513/
https://www.ncbi.nlm.nih.gov/pubmed/24228595
http://dx.doi.org/10.1186/1741-7007-11-102
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author Kaeberlein, Matt
author_facet Kaeberlein, Matt
author_sort Kaeberlein, Matt
collection PubMed
description Understanding the genetic basis of age-related diseases is a critical step toward developing therapies that promote healthy aging. Numerous genes have been identified that modulate lifespan, but the influence of natural variation in aging has not been well studied. A new report utilizing a transgenic protein aggregation model in Caenorhabditis elegans has provided important tools and insights into the relationship between natural genetic variation, protein aggregation, and age-related pathology. See research article: http://www.biomedcentral.com/1741-7007/11/100
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spelling pubmed-38495132013-12-05 Deciphering the role of natural variation in age-related protein homeostasis Kaeberlein, Matt BMC Biol Commentary Understanding the genetic basis of age-related diseases is a critical step toward developing therapies that promote healthy aging. Numerous genes have been identified that modulate lifespan, but the influence of natural variation in aging has not been well studied. A new report utilizing a transgenic protein aggregation model in Caenorhabditis elegans has provided important tools and insights into the relationship between natural genetic variation, protein aggregation, and age-related pathology. See research article: http://www.biomedcentral.com/1741-7007/11/100 BioMed Central 2013-09-30 /pmc/articles/PMC3849513/ /pubmed/24228595 http://dx.doi.org/10.1186/1741-7007-11-102 Text en Copyright © 2013 Kaeberlein; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Kaeberlein, Matt
Deciphering the role of natural variation in age-related protein homeostasis
title Deciphering the role of natural variation in age-related protein homeostasis
title_full Deciphering the role of natural variation in age-related protein homeostasis
title_fullStr Deciphering the role of natural variation in age-related protein homeostasis
title_full_unstemmed Deciphering the role of natural variation in age-related protein homeostasis
title_short Deciphering the role of natural variation in age-related protein homeostasis
title_sort deciphering the role of natural variation in age-related protein homeostasis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849513/
https://www.ncbi.nlm.nih.gov/pubmed/24228595
http://dx.doi.org/10.1186/1741-7007-11-102
work_keys_str_mv AT kaeberleinmatt decipheringtheroleofnaturalvariationinagerelatedproteinhomeostasis

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