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Urinary adiponectin concentration is positively associated with micro- and macro-vascular complications

BACKGROUND: A relationship between plasma adiponectin level and a number of metabolic conditions, including insulin resistance, obesity, and type 2 diabetes, has been reported. This study aimed to assess whether urinary adiponectin concentration is correlated with vascular complications. METHODS: Th...

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Autores principales: Jeon, Won Seon, Park, Ji Woo, Lee, Namseok, Park, Se Eun, Rhee, Eun Jung, Lee, Won Young, Oh, Ki Won, Park, Sung Woo, Park, Cheol-Young, Youn, Byung-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849544/
https://www.ncbi.nlm.nih.gov/pubmed/24073643
http://dx.doi.org/10.1186/1475-2840-12-137
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author Jeon, Won Seon
Park, Ji Woo
Lee, Namseok
Park, Se Eun
Rhee, Eun Jung
Lee, Won Young
Oh, Ki Won
Park, Sung Woo
Park, Cheol-Young
Youn, Byung-Soo
author_facet Jeon, Won Seon
Park, Ji Woo
Lee, Namseok
Park, Se Eun
Rhee, Eun Jung
Lee, Won Young
Oh, Ki Won
Park, Sung Woo
Park, Cheol-Young
Youn, Byung-Soo
author_sort Jeon, Won Seon
collection PubMed
description BACKGROUND: A relationship between plasma adiponectin level and a number of metabolic conditions, including insulin resistance, obesity, and type 2 diabetes, has been reported. This study aimed to assess whether urinary adiponectin concentration is correlated with vascular complications. METHODS: The study comprised 708 subjects who enrolled in the Seoul Metro City Diabetes Prevention Program and were carefully monitored from September 2008 to December 2008. Levels of urinary adiponectin were measured using an enzyme linked immunosorbent assay (ELISA) kit (AdipoGen, Korea). Urinary albumin excretion was assessed by the ratio of urinary albumin to creatinine (A/C ratio). Participants were divided into three groups based on tertiles of urinary adiponectin concentration, and we investigated whether urinary adiponectin levels are associated with microalbuminuria and pulse wave velocity. RESULTS: Urinary adiponectin concentrations were significantly higher in subjects with microalbuminuria than subjects with normoalbuminuria (P < 0.001). Urinary adiponectin concentration was positively correlated with age, fasting plasma glucose level, HbA1C level, triglyceride level, HOMA-IR, systolic/diastolic blood pressure, and urinary A/C ratio (all P < 0.05). Subjects in the highest tertile of urinary adiponectin concentration had an increased likelihood of microalbuminuria than those in the lowest tertile (Odds ratio (OR), 6.437; 95% confidence interval (CI), 4.202 to 9.862; P < 0.001). After adjusting for age, sex, and estimated creatinine clearance rate (eCcr), the OR remained significant (OR, 5.607; 95% CI, 3.562 to 8.828; P < 0.001). Backward multiple linear regression analysis revealed urinary adiponectin concentration to be a significant determinant of mean brachial-ankle pulse wave velocity (baPWV). CONCLUSIONS: An increased urinary adiponectin concentration is significantly associated with microalbuminuria and increased mean baPWV. These results suggest that urinary adiponectin may play an important role as a biomarker for vascular dysfunction.
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spelling pubmed-38495442013-12-05 Urinary adiponectin concentration is positively associated with micro- and macro-vascular complications Jeon, Won Seon Park, Ji Woo Lee, Namseok Park, Se Eun Rhee, Eun Jung Lee, Won Young Oh, Ki Won Park, Sung Woo Park, Cheol-Young Youn, Byung-Soo Cardiovasc Diabetol Original Investigation BACKGROUND: A relationship between plasma adiponectin level and a number of metabolic conditions, including insulin resistance, obesity, and type 2 diabetes, has been reported. This study aimed to assess whether urinary adiponectin concentration is correlated with vascular complications. METHODS: The study comprised 708 subjects who enrolled in the Seoul Metro City Diabetes Prevention Program and were carefully monitored from September 2008 to December 2008. Levels of urinary adiponectin were measured using an enzyme linked immunosorbent assay (ELISA) kit (AdipoGen, Korea). Urinary albumin excretion was assessed by the ratio of urinary albumin to creatinine (A/C ratio). Participants were divided into three groups based on tertiles of urinary adiponectin concentration, and we investigated whether urinary adiponectin levels are associated with microalbuminuria and pulse wave velocity. RESULTS: Urinary adiponectin concentrations were significantly higher in subjects with microalbuminuria than subjects with normoalbuminuria (P < 0.001). Urinary adiponectin concentration was positively correlated with age, fasting plasma glucose level, HbA1C level, triglyceride level, HOMA-IR, systolic/diastolic blood pressure, and urinary A/C ratio (all P < 0.05). Subjects in the highest tertile of urinary adiponectin concentration had an increased likelihood of microalbuminuria than those in the lowest tertile (Odds ratio (OR), 6.437; 95% confidence interval (CI), 4.202 to 9.862; P < 0.001). After adjusting for age, sex, and estimated creatinine clearance rate (eCcr), the OR remained significant (OR, 5.607; 95% CI, 3.562 to 8.828; P < 0.001). Backward multiple linear regression analysis revealed urinary adiponectin concentration to be a significant determinant of mean brachial-ankle pulse wave velocity (baPWV). CONCLUSIONS: An increased urinary adiponectin concentration is significantly associated with microalbuminuria and increased mean baPWV. These results suggest that urinary adiponectin may play an important role as a biomarker for vascular dysfunction. BioMed Central 2013-09-28 /pmc/articles/PMC3849544/ /pubmed/24073643 http://dx.doi.org/10.1186/1475-2840-12-137 Text en Copyright © 2013 Jeon et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Investigation
Jeon, Won Seon
Park, Ji Woo
Lee, Namseok
Park, Se Eun
Rhee, Eun Jung
Lee, Won Young
Oh, Ki Won
Park, Sung Woo
Park, Cheol-Young
Youn, Byung-Soo
Urinary adiponectin concentration is positively associated with micro- and macro-vascular complications
title Urinary adiponectin concentration is positively associated with micro- and macro-vascular complications
title_full Urinary adiponectin concentration is positively associated with micro- and macro-vascular complications
title_fullStr Urinary adiponectin concentration is positively associated with micro- and macro-vascular complications
title_full_unstemmed Urinary adiponectin concentration is positively associated with micro- and macro-vascular complications
title_short Urinary adiponectin concentration is positively associated with micro- and macro-vascular complications
title_sort urinary adiponectin concentration is positively associated with micro- and macro-vascular complications
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849544/
https://www.ncbi.nlm.nih.gov/pubmed/24073643
http://dx.doi.org/10.1186/1475-2840-12-137
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