Fractal-like kinetics of intracellular enzymatic reactions: a chemical framework of endotoxin tolerance and a possible non-specific contribution of macromolecular crowding to cross-tolerance

BACKGROUND: The response to endotoxin (LPS), and subsequent signal transduction lead to the production of cytokines such as tumor necrosis factor-α (TNF-α) by innate immune cells. Cells or organisms pretreated with endotoxin enter into a transient state of hyporesponsiveness, referred to as endotoxi...

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Detalles Bibliográficos
Autores principales: Vasilescu, Catalin, Olteanu, Mircea, Flondor, Paul, Calin, George A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849556/
https://www.ncbi.nlm.nih.gov/pubmed/24034421
http://dx.doi.org/10.1186/1742-4682-10-55

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