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Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice

BACKGROUND: CR8 is a second generation inhibitor of cyclin-dependent kinases derived from roscovitine. CR8 was shown to be 50–100 fold more potent than roscovitine in inducing apoptosis in different tumor cell lines. In the present investigation, we have established an analytical method for the quan...

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Detalles Bibliográficos
Autores principales:	Sallam, Hatem, El-Serafi, Ibrahim, Meijer, Laurent, Hassan, Moustapha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849647/ https://www.ncbi.nlm.nih.gov/pubmed/24079553 http://dx.doi.org/10.1186/2050-6511-14-50

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