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Forced expression of the DEK-NUP214 fusion protein promotes proliferation dependent on upregulation of mTOR

BACKGROUND: The t(6;9)(p23;q34) chromosomal translocation is found in 1% of acute myeloid leukemia and encodes the fusion protein DEK-NUP214 (formerly DEK-CAN) with largely uncharacterized functions. METHODS: We expressed DEK-NUP214 in the myeloid cell lines U937 and PL-21 and studied the effects on...

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Detalles Bibliográficos
Autores principales:	Sandén, Carl, Ageberg, Malin, Petersson, Jessica, Lennartsson, Andreas, Gullberg, Urban
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849736/ https://www.ncbi.nlm.nih.gov/pubmed/24073922 http://dx.doi.org/10.1186/1471-2407-13-440

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