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Forced expression of the DEK-NUP214 fusion protein promotes proliferation dependent on upregulation of mTOR
BACKGROUND: The t(6;9)(p23;q34) chromosomal translocation is found in 1% of acute myeloid leukemia and encodes the fusion protein DEK-NUP214 (formerly DEK-CAN) with largely uncharacterized functions. METHODS: We expressed DEK-NUP214 in the myeloid cell lines U937 and PL-21 and studied the effects on...
Autores principales: | Sandén, Carl, Ageberg, Malin, Petersson, Jessica, Lennartsson, Andreas, Gullberg, Urban |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849736/ https://www.ncbi.nlm.nih.gov/pubmed/24073922 http://dx.doi.org/10.1186/1471-2407-13-440 |
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