Cargando…
Tissue Injury and Related Mediators of Pain Exacerbation
Tissue injury and inflammation result in release of various mediators that promote ongoing pain or pain hypersensitivity against mechanical, thermal and chemical stimuli. Pro-nociceptive mediators activate primary afferent neurons directly or indirectly to enhance nociceptive signal transmission to...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849785/ https://www.ncbi.nlm.nih.gov/pubmed/24396335 http://dx.doi.org/10.2174/1570159X11311060003 |
_version_ | 1782293988845289472 |
---|---|
author | Amaya, Fumimasa Izumi, Yuta Matsuda, Megumi Sasaki, Mika |
author_facet | Amaya, Fumimasa Izumi, Yuta Matsuda, Megumi Sasaki, Mika |
author_sort | Amaya, Fumimasa |
collection | PubMed |
description | Tissue injury and inflammation result in release of various mediators that promote ongoing pain or pain hypersensitivity against mechanical, thermal and chemical stimuli. Pro-nociceptive mediators activate primary afferent neurons directly or indirectly to enhance nociceptive signal transmission to the central nervous system. Excitation of primary afferents by peripherally originating mediators, so-called “peripheral sensitization”, is a hallmark of tissue injury-related pain. Many kinds of pro-nociceptive mediators, including ATP, glutamate, kinins, cytokines and tropic factors, synthesized at the damaged tissue, contribute to the development of peripheral sensitization. In the present review we will discuss the molecular mechanisms of peripheral sensitization following tissue injury. |
format | Online Article Text |
id | pubmed-3849785 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-38497852014-06-01 Tissue Injury and Related Mediators of Pain Exacerbation Amaya, Fumimasa Izumi, Yuta Matsuda, Megumi Sasaki, Mika Curr Neuropharmacol Article Tissue injury and inflammation result in release of various mediators that promote ongoing pain or pain hypersensitivity against mechanical, thermal and chemical stimuli. Pro-nociceptive mediators activate primary afferent neurons directly or indirectly to enhance nociceptive signal transmission to the central nervous system. Excitation of primary afferents by peripherally originating mediators, so-called “peripheral sensitization”, is a hallmark of tissue injury-related pain. Many kinds of pro-nociceptive mediators, including ATP, glutamate, kinins, cytokines and tropic factors, synthesized at the damaged tissue, contribute to the development of peripheral sensitization. In the present review we will discuss the molecular mechanisms of peripheral sensitization following tissue injury. Bentham Science Publishers 2013-12 2013-12 /pmc/articles/PMC3849785/ /pubmed/24396335 http://dx.doi.org/10.2174/1570159X11311060003 Text en ©2013 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Amaya, Fumimasa Izumi, Yuta Matsuda, Megumi Sasaki, Mika Tissue Injury and Related Mediators of Pain Exacerbation |
title | Tissue Injury and Related Mediators of Pain Exacerbation |
title_full | Tissue Injury and Related Mediators of Pain Exacerbation |
title_fullStr | Tissue Injury and Related Mediators of Pain Exacerbation |
title_full_unstemmed | Tissue Injury and Related Mediators of Pain Exacerbation |
title_short | Tissue Injury and Related Mediators of Pain Exacerbation |
title_sort | tissue injury and related mediators of pain exacerbation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849785/ https://www.ncbi.nlm.nih.gov/pubmed/24396335 http://dx.doi.org/10.2174/1570159X11311060003 |
work_keys_str_mv | AT amayafumimasa tissueinjuryandrelatedmediatorsofpainexacerbation AT izumiyuta tissueinjuryandrelatedmediatorsofpainexacerbation AT matsudamegumi tissueinjuryandrelatedmediatorsofpainexacerbation AT sasakimika tissueinjuryandrelatedmediatorsofpainexacerbation |