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Tissue Injury and Related Mediators of Pain Exacerbation

Tissue injury and inflammation result in release of various mediators that promote ongoing pain or pain hypersensitivity against mechanical, thermal and chemical stimuli. Pro-nociceptive mediators activate primary afferent neurons directly or indirectly to enhance nociceptive signal transmission to...

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Detalles Bibliográficos
Autores principales: Amaya, Fumimasa, Izumi, Yuta, Matsuda, Megumi, Sasaki, Mika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849785/
https://www.ncbi.nlm.nih.gov/pubmed/24396335
http://dx.doi.org/10.2174/1570159X11311060003
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author Amaya, Fumimasa
Izumi, Yuta
Matsuda, Megumi
Sasaki, Mika
author_facet Amaya, Fumimasa
Izumi, Yuta
Matsuda, Megumi
Sasaki, Mika
author_sort Amaya, Fumimasa
collection PubMed
description Tissue injury and inflammation result in release of various mediators that promote ongoing pain or pain hypersensitivity against mechanical, thermal and chemical stimuli. Pro-nociceptive mediators activate primary afferent neurons directly or indirectly to enhance nociceptive signal transmission to the central nervous system. Excitation of primary afferents by peripherally originating mediators, so-called “peripheral sensitization”, is a hallmark of tissue injury-related pain. Many kinds of pro-nociceptive mediators, including ATP, glutamate, kinins, cytokines and tropic factors, synthesized at the damaged tissue, contribute to the development of peripheral sensitization. In the present review we will discuss the molecular mechanisms of peripheral sensitization following tissue injury.
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spelling pubmed-38497852014-06-01 Tissue Injury and Related Mediators of Pain Exacerbation Amaya, Fumimasa Izumi, Yuta Matsuda, Megumi Sasaki, Mika Curr Neuropharmacol Article Tissue injury and inflammation result in release of various mediators that promote ongoing pain or pain hypersensitivity against mechanical, thermal and chemical stimuli. Pro-nociceptive mediators activate primary afferent neurons directly or indirectly to enhance nociceptive signal transmission to the central nervous system. Excitation of primary afferents by peripherally originating mediators, so-called “peripheral sensitization”, is a hallmark of tissue injury-related pain. Many kinds of pro-nociceptive mediators, including ATP, glutamate, kinins, cytokines and tropic factors, synthesized at the damaged tissue, contribute to the development of peripheral sensitization. In the present review we will discuss the molecular mechanisms of peripheral sensitization following tissue injury. Bentham Science Publishers 2013-12 2013-12 /pmc/articles/PMC3849785/ /pubmed/24396335 http://dx.doi.org/10.2174/1570159X11311060003 Text en ©2013 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Amaya, Fumimasa
Izumi, Yuta
Matsuda, Megumi
Sasaki, Mika
Tissue Injury and Related Mediators of Pain Exacerbation
title Tissue Injury and Related Mediators of Pain Exacerbation
title_full Tissue Injury and Related Mediators of Pain Exacerbation
title_fullStr Tissue Injury and Related Mediators of Pain Exacerbation
title_full_unstemmed Tissue Injury and Related Mediators of Pain Exacerbation
title_short Tissue Injury and Related Mediators of Pain Exacerbation
title_sort tissue injury and related mediators of pain exacerbation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849785/
https://www.ncbi.nlm.nih.gov/pubmed/24396335
http://dx.doi.org/10.2174/1570159X11311060003
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