Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics
BACKGROUND: It has been suggested that smoking asthmatics benefit less from corticosteroid treatment than never-smoking asthmatics. We investigated differences in blood and sputum inflammatory profiles between ex-, current-, and never-smokers and assessed their ICS treatment response after 2-week an...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849864/ https://www.ncbi.nlm.nih.gov/pubmed/24053453 http://dx.doi.org/10.1186/1471-2466-13-58 |
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author | Telenga, Eef D Kerstjens, Huib A M ten Hacken, Nick H T Postma, Dirkje S van den Berge, Maarten |
author_facet | Telenga, Eef D Kerstjens, Huib A M ten Hacken, Nick H T Postma, Dirkje S van den Berge, Maarten |
author_sort | Telenga, Eef D |
collection | PubMed |
description | BACKGROUND: It has been suggested that smoking asthmatics benefit less from corticosteroid treatment than never-smoking asthmatics. We investigated differences in blood and sputum inflammatory profiles between ex-, current-, and never-smokers and assessed their ICS treatment response after 2-week and 1-year treatment. METHODS: We analyzed FEV(1), PC(20) methacholine and PC(20) AMP, (differential) cell counts in sputum and blood in ex-, current- and never-smokers at baseline (n=114), after 2-week treatment with fluticasone 500 or 2000 μg/day (n=76) and after 1-year treatment with fluticasone 500 μg/day or a variable dose of fluticasone based on a self-management plan (n=64). RESULTS: A total of 114 patients were included (29 ex-, 30 current- and 55 never-smokers. At baseline, ex- and current-smokers had less eosinophils in sputum and blood than never-smokers. Blood neutrophil counts were higher in current- than in never-smokers. A higher number of cigarettes smoked daily was associated with lower blood and sputum eosinophils. After 2-week ICS treatment, FEV(1) %predicted improved less in current-smokers than never-smokers (2.4% versus 8.1%, p=0.010) and ex-smokers tended to improve less than never-smokers (4.1%, p=0.067). In contrast, no differences in ICS treatment response in lung function or inflammatory cells were found between the three groups after 1 year. CONCLUSIONS: Ex- and current-smokers have less eosinophils and more neutrophils in their sputum and blood than never-smokers. Although ex- and current-smokers have a reduced short-term corticosteroid treatment response, we did not find a difference in their long-term treatment response. |
format | Online Article Text |
id | pubmed-3849864 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-38498642013-12-05 Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics Telenga, Eef D Kerstjens, Huib A M ten Hacken, Nick H T Postma, Dirkje S van den Berge, Maarten BMC Pulm Med Research Article BACKGROUND: It has been suggested that smoking asthmatics benefit less from corticosteroid treatment than never-smoking asthmatics. We investigated differences in blood and sputum inflammatory profiles between ex-, current-, and never-smokers and assessed their ICS treatment response after 2-week and 1-year treatment. METHODS: We analyzed FEV(1), PC(20) methacholine and PC(20) AMP, (differential) cell counts in sputum and blood in ex-, current- and never-smokers at baseline (n=114), after 2-week treatment with fluticasone 500 or 2000 μg/day (n=76) and after 1-year treatment with fluticasone 500 μg/day or a variable dose of fluticasone based on a self-management plan (n=64). RESULTS: A total of 114 patients were included (29 ex-, 30 current- and 55 never-smokers. At baseline, ex- and current-smokers had less eosinophils in sputum and blood than never-smokers. Blood neutrophil counts were higher in current- than in never-smokers. A higher number of cigarettes smoked daily was associated with lower blood and sputum eosinophils. After 2-week ICS treatment, FEV(1) %predicted improved less in current-smokers than never-smokers (2.4% versus 8.1%, p=0.010) and ex-smokers tended to improve less than never-smokers (4.1%, p=0.067). In contrast, no differences in ICS treatment response in lung function or inflammatory cells were found between the three groups after 1 year. CONCLUSIONS: Ex- and current-smokers have less eosinophils and more neutrophils in their sputum and blood than never-smokers. Although ex- and current-smokers have a reduced short-term corticosteroid treatment response, we did not find a difference in their long-term treatment response. BioMed Central 2013-09-22 /pmc/articles/PMC3849864/ /pubmed/24053453 http://dx.doi.org/10.1186/1471-2466-13-58 Text en Copyright © 2013 Telenga et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Telenga, Eef D Kerstjens, Huib A M ten Hacken, Nick H T Postma, Dirkje S van den Berge, Maarten Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics |
title | Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics |
title_full | Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics |
title_fullStr | Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics |
title_full_unstemmed | Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics |
title_short | Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics |
title_sort | inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849864/ https://www.ncbi.nlm.nih.gov/pubmed/24053453 http://dx.doi.org/10.1186/1471-2466-13-58 |
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