Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics

BACKGROUND: It has been suggested that smoking asthmatics benefit less from corticosteroid treatment than never-smoking asthmatics. We investigated differences in blood and sputum inflammatory profiles between ex-, current-, and never-smokers and assessed their ICS treatment response after 2-week an...

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Autores principales: Telenga, Eef D, Kerstjens, Huib A M, ten Hacken, Nick H T, Postma, Dirkje S, van den Berge, Maarten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849864/
https://www.ncbi.nlm.nih.gov/pubmed/24053453
http://dx.doi.org/10.1186/1471-2466-13-58
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author Telenga, Eef D
Kerstjens, Huib A M
ten Hacken, Nick H T
Postma, Dirkje S
van den Berge, Maarten
author_facet Telenga, Eef D
Kerstjens, Huib A M
ten Hacken, Nick H T
Postma, Dirkje S
van den Berge, Maarten
author_sort Telenga, Eef D
collection PubMed
description BACKGROUND: It has been suggested that smoking asthmatics benefit less from corticosteroid treatment than never-smoking asthmatics. We investigated differences in blood and sputum inflammatory profiles between ex-, current-, and never-smokers and assessed their ICS treatment response after 2-week and 1-year treatment. METHODS: We analyzed FEV(1), PC(20) methacholine and PC(20) AMP, (differential) cell counts in sputum and blood in ex-, current- and never-smokers at baseline (n=114), after 2-week treatment with fluticasone 500 or 2000 μg/day (n=76) and after 1-year treatment with fluticasone 500 μg/day or a variable dose of fluticasone based on a self-management plan (n=64). RESULTS: A total of 114 patients were included (29 ex-, 30 current- and 55 never-smokers. At baseline, ex- and current-smokers had less eosinophils in sputum and blood than never-smokers. Blood neutrophil counts were higher in current- than in never-smokers. A higher number of cigarettes smoked daily was associated with lower blood and sputum eosinophils. After 2-week ICS treatment, FEV(1) %predicted improved less in current-smokers than never-smokers (2.4% versus 8.1%, p=0.010) and ex-smokers tended to improve less than never-smokers (4.1%, p=0.067). In contrast, no differences in ICS treatment response in lung function or inflammatory cells were found between the three groups after 1 year. CONCLUSIONS: Ex- and current-smokers have less eosinophils and more neutrophils in their sputum and blood than never-smokers. Although ex- and current-smokers have a reduced short-term corticosteroid treatment response, we did not find a difference in their long-term treatment response.
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spelling pubmed-38498642013-12-05 Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics Telenga, Eef D Kerstjens, Huib A M ten Hacken, Nick H T Postma, Dirkje S van den Berge, Maarten BMC Pulm Med Research Article BACKGROUND: It has been suggested that smoking asthmatics benefit less from corticosteroid treatment than never-smoking asthmatics. We investigated differences in blood and sputum inflammatory profiles between ex-, current-, and never-smokers and assessed their ICS treatment response after 2-week and 1-year treatment. METHODS: We analyzed FEV(1), PC(20) methacholine and PC(20) AMP, (differential) cell counts in sputum and blood in ex-, current- and never-smokers at baseline (n=114), after 2-week treatment with fluticasone 500 or 2000 μg/day (n=76) and after 1-year treatment with fluticasone 500 μg/day or a variable dose of fluticasone based on a self-management plan (n=64). RESULTS: A total of 114 patients were included (29 ex-, 30 current- and 55 never-smokers. At baseline, ex- and current-smokers had less eosinophils in sputum and blood than never-smokers. Blood neutrophil counts were higher in current- than in never-smokers. A higher number of cigarettes smoked daily was associated with lower blood and sputum eosinophils. After 2-week ICS treatment, FEV(1) %predicted improved less in current-smokers than never-smokers (2.4% versus 8.1%, p=0.010) and ex-smokers tended to improve less than never-smokers (4.1%, p=0.067). In contrast, no differences in ICS treatment response in lung function or inflammatory cells were found between the three groups after 1 year. CONCLUSIONS: Ex- and current-smokers have less eosinophils and more neutrophils in their sputum and blood than never-smokers. Although ex- and current-smokers have a reduced short-term corticosteroid treatment response, we did not find a difference in their long-term treatment response. BioMed Central 2013-09-22 /pmc/articles/PMC3849864/ /pubmed/24053453 http://dx.doi.org/10.1186/1471-2466-13-58 Text en Copyright © 2013 Telenga et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Telenga, Eef D
Kerstjens, Huib A M
ten Hacken, Nick H T
Postma, Dirkje S
van den Berge, Maarten
Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics
title Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics
title_full Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics
title_fullStr Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics
title_full_unstemmed Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics
title_short Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics
title_sort inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849864/
https://www.ncbi.nlm.nih.gov/pubmed/24053453
http://dx.doi.org/10.1186/1471-2466-13-58
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