RON promotes the metastatic spread of breast carcinomas by subverting antitumor immune responses

The MSP/RON signaling pathway favors the conversion of micrometastatic lesions to overt metastases by suppressing antitumor immune responses. The loss of RON functions in the host potentiates tumor-specific CD8(+) T-cell responses, hence inhibiting the outgrowth of metastatic cancer cells. Thus, RON...

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Detalles Bibliográficos
Autores principales: Eyob, Henok, Ekiz, Huseyin Atakan, Welm, Alana L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850023/
https://www.ncbi.nlm.nih.gov/pubmed/24327933
http://dx.doi.org/10.4161/onci.25670
Descripción
Sumario:The MSP/RON signaling pathway favors the conversion of micrometastatic lesions to overt metastases by suppressing antitumor immune responses. The loss of RON functions in the host potentiates tumor-specific CD8(+) T-cell responses, hence inhibiting the outgrowth of metastatic cancer cells. Thus, RON inhibitors may potentially prevent the outgrowth of micrometastases in cancer patients.

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