RON promotes the metastatic spread of breast carcinomas by subverting antitumor immune responses

The MSP/RON signaling pathway favors the conversion of micrometastatic lesions to overt metastases by suppressing antitumor immune responses. The loss of RON functions in the host potentiates tumor-specific CD8(+) T-cell responses, hence inhibiting the outgrowth of metastatic cancer cells. Thus, RON...

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Autores principales: Eyob, Henok, Ekiz, Huseyin Atakan, Welm, Alana L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850023/
https://www.ncbi.nlm.nih.gov/pubmed/24327933
http://dx.doi.org/10.4161/onci.25670
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author Eyob, Henok
Ekiz, Huseyin Atakan
Welm, Alana L
author_facet Eyob, Henok
Ekiz, Huseyin Atakan
Welm, Alana L
author_sort Eyob, Henok
collection PubMed
description The MSP/RON signaling pathway favors the conversion of micrometastatic lesions to overt metastases by suppressing antitumor immune responses. The loss of RON functions in the host potentiates tumor-specific CD8(+) T-cell responses, hence inhibiting the outgrowth of metastatic cancer cells. Thus, RON inhibitors may potentially prevent the outgrowth of micrometastases in cancer patients.
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spelling pubmed-38500232013-12-10 RON promotes the metastatic spread of breast carcinomas by subverting antitumor immune responses Eyob, Henok Ekiz, Huseyin Atakan Welm, Alana L Oncoimmunology Author's View The MSP/RON signaling pathway favors the conversion of micrometastatic lesions to overt metastases by suppressing antitumor immune responses. The loss of RON functions in the host potentiates tumor-specific CD8(+) T-cell responses, hence inhibiting the outgrowth of metastatic cancer cells. Thus, RON inhibitors may potentially prevent the outgrowth of micrometastases in cancer patients. Landes Bioscience 2013-09-01 2013-08-14 /pmc/articles/PMC3850023/ /pubmed/24327933 http://dx.doi.org/10.4161/onci.25670 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Eyob, Henok
Ekiz, Huseyin Atakan
Welm, Alana L
RON promotes the metastatic spread of breast carcinomas by subverting antitumor immune responses
title RON promotes the metastatic spread of breast carcinomas by subverting antitumor immune responses
title_full RON promotes the metastatic spread of breast carcinomas by subverting antitumor immune responses
title_fullStr RON promotes the metastatic spread of breast carcinomas by subverting antitumor immune responses
title_full_unstemmed RON promotes the metastatic spread of breast carcinomas by subverting antitumor immune responses
title_short RON promotes the metastatic spread of breast carcinomas by subverting antitumor immune responses
title_sort ron promotes the metastatic spread of breast carcinomas by subverting antitumor immune responses
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850023/
https://www.ncbi.nlm.nih.gov/pubmed/24327933
http://dx.doi.org/10.4161/onci.25670
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AT welmalanal ronpromotesthemetastaticspreadofbreastcarcinomasbysubvertingantitumorimmuneresponses

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