Cargando…

RON promotes the metastatic spread of breast carcinomas by subverting antitumor immune responses

The MSP/RON signaling pathway favors the conversion of micrometastatic lesions to overt metastases by suppressing antitumor immune responses. The loss of RON functions in the host potentiates tumor-specific CD8(+) T-cell responses, hence inhibiting the outgrowth of metastatic cancer cells. Thus, RON...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eyob, Henok, Ekiz, Huseyin Atakan, Welm, Alana L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2013
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850023/ https://www.ncbi.nlm.nih.gov/pubmed/24327933 http://dx.doi.org/10.4161/onci.25670

Ejemplares similares

Blocking Short-Form Ron Eliminates Breast Cancer Metastases through Accumulation of Stem-Like CD4(+) T Cells That Subvert Immunosuppression
por: Lai, Shu-Chin Alicia, et al.
Publicado: (2021)

Inhibition of RON kinase potentiates anti-CTLA-4 immunotherapy to shrink breast tumors and prevent metastatic outgrowth
por: Ekiz, Huseyin Atakan, et al.
Publicado: (2018)

Polyamine blockade promotes antitumor immunity
por: Hayes, Candace S, et al.
Publicado: (2014)

Retinoic acid on stage in antitumor immunity
por: Guo, Yanxia, et al.
Publicado: (2013)

Targeting coagulation to unlock antitumor immunity?
por: Galmiche, Antoine, et al.
Publicado: (2022)

Catechins and antitumor immunity: Not MDSC’s cup of tea
por: Santilli, Giorgia, et al.
Publicado: (2013)

Crucial role of inflammatory monocytes in antitumor immunity
por: Pommier, Arnaud, et al.
Publicado: (2013)

Engineering effective T-cell based antitumor immunity
por: Gruber, Thomas, et al.
Publicado: (2013)

New role for antigen-presenting activated pDCs in promoting Th17 cells and impacting antitumor immunity
por: Guéry, Leslie, et al.
Publicado: (2015)

Potentiating antitumor immunity with αGC-loaded exosomes
por: Gehrmann, Ulf, et al.
Publicado: (2013)

PD-L1 expression and tumor-infiltrating lymphocytes: Revisiting the antitumor immune response potential in breast cancer
por: Schalper, Kurt A
Publicado: (2014)

High endothelial venules: Help or hindrance in the quest for antitumor immunity?
por: Gallimore, Awen, et al.
Publicado: (2013)

Activation of systemic antitumor immunity via TRAIL-induced apoptosis
por: James, Britnie R., et al.
Publicado: (2012)

Tumor spread or siege immunity: dissemination to distant metastasis or not
por: Bindea, Gabriela, et al.
Publicado: (2021)

A Janus-faced role of the unfolded protein response in antitumor immunity
por: Mahadevan, Navin R., et al.
Publicado: (2013)

Monocyte-derived dendritic cells: Emerging players in the antitumor immune response
por: Kuhn, Sabine, et al.
Publicado: (2013)

B7-H4 is a positive regulator of antitumor immunity
por: Rahbar, Ramtin, et al.
Publicado: (2015)

A clinically useful approach to enhance immunological memory and antitumor immunity
por: Berezhnoy, Alex, et al.
Publicado: (2014)

Targeting human CD27 with an agonist antibody stimulates T-cell activation and antitumor immunity
por: Thomas, Lawrence J, et al.
Publicado: (2014)

Multiverse of immune microenvironment in metastatic colorectal cancer
por: Van den Eynde, Marc, et al.
Publicado: (2020)

Tertiary lymphoid structures in human lung cancers, a new driver of antitumor immune responses
por: Goc, Jérémy, et al.
Publicado: (2014)

Is preexisting antitumor CD4 T cell response indispensable for the chemotherapy induced immune regression of cancer?
por: Godet, Yann, et al.
Publicado: (2012)

Push and release: TLR9 activation plus STAT3 blockade for systemic antitumor immunity
por: Kortylewski, Marcin, et al.
Publicado: (2014)

Two is better than one: Complementing oncolytic virotherapy with gemcitabine to potentiate antitumor immune responses
por: Gujar, Shashi A, et al.
Publicado: (2014)

Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response
por: Sosnowska, Anna, et al.
Publicado: (2019)

Stress-induced metastatic niches in breast cancer
por: Oskarsson, Thordur
Publicado: (2020)

The short and sweet of T-cell therapy: Restraining glycolysis enhances the formation of immunological memory and antitumor immune responses
por: Sukumar, Madhusudhanan, et al.
Publicado: (2014)

Antibody-based depletion of Foxp3+ T cells potentiates antitumor immune memory stimulated by mTOR inhibition
por: Kim, Hyung L
Publicado: (2014)

Licensing of γδT cells for professional antigen presentation: A new role for antibodies in regulation of antitumor immune responses
por: Anderson, John, et al.
Publicado: (2012)

mTORC1 is a key mediator of RON-dependent breast cancer metastasis with therapeutic potential
por: Faham, Najme, et al.
Publicado: (2018)

A novel preclinical murine model of immune-mediated metastatic dormancy
por: Romero, Irene, et al.
Publicado: (2014)

A(2A) blockade enhances anti-metastatic immune responses
por: Beavis, Paul A, et al.
Publicado: (2013)

A novel actor in antitumoral immunity: The thymus-specific serine protease TSSP/PRSS16 involved in CD4(+) T-cell maturation
por: Brisson, Lydie, et al.
Publicado: (2015)

Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies
por: Verbrugge, Inge, et al.
Publicado: (2012)

Evidence of synergy with combined BRAF-targeted therapy and immune checkpoint blockade for metastatic melanoma
por: Cooper, Zachary A, et al.
Publicado: (2014)

Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide
por: Chen, Xin, et al.
Publicado: (2014)

Arming NK cells with enhanced antitumor activity: CARs and beyond
por: Oberoi, Pranav, et al.
Publicado: (2013)

The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity
por: Wong, Hing C, et al.
Publicado: (2013)

Role of the complement system in NK cell-mediated antitumor T-cell responses
por: Janelle, Valérie, et al.
Publicado: (2014)

miRNA-mediated GALNT modulation of invasion and immune suppression: A sweet deal for metastatic cells
por: Gaziel-Sovran, Avital, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_68tpuv4b91a85rt01bet8rlgqr