CX3CL1 at the crossroad of EGF signals: Relevance for the progression of ERBB2(+) breast carcinoma

Inflammatory mediators can play a dual role in oncogenesis and tumor progression. CX3CL1, a chemokine previously implicated in natural killer cell- and CD8(+) T cell-mediated antitumor immune responses, has now been identified as a promoter of ERBB2-expressing breast carcinomas as it cross-activates...

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Detalles Bibliográficos
Autores principales: Tardáguila, Manuel, Mañes, Santos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850216/
https://www.ncbi.nlm.nih.gov/pubmed/24319638
http://dx.doi.org/10.4161/onci.25669
Descripción
Sumario:Inflammatory mediators can play a dual role in oncogenesis and tumor progression. CX3CL1, a chemokine previously implicated in natural killer cell- and CD8(+) T cell-mediated antitumor immune responses, has now been identified as a promoter of ERBB2-expressing breast carcinomas as it cross-activates members of the epidermal growth factor receptor family.

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