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Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells

Despite its efficacy and widespread use, radiation therapy is often associated with local or distal tumor relapse. We have recently found that CD8(+) T cells and their cytokines are essential for maintaining irradiated neoplasms under control. In line with this notion, enhancing T-cell functions by...

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Detalles Bibliográficos
Autores principales: Liang, Hua, Deng, Liufu, Burnette, Byron, Weichselbaum, Ralph R, Fu, Yang-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850275/
https://www.ncbi.nlm.nih.gov/pubmed/24319637
http://dx.doi.org/10.4161/onci.25668
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author Liang, Hua
Deng, Liufu
Burnette, Byron
Weichselbaum, Ralph R
Fu, Yang-Xin
author_facet Liang, Hua
Deng, Liufu
Burnette, Byron
Weichselbaum, Ralph R
Fu, Yang-Xin
author_sort Liang, Hua
collection PubMed
description Despite its efficacy and widespread use, radiation therapy is often associated with local or distal tumor relapse. We have recently found that CD8(+) T cells and their cytokines are essential for maintaining irradiated neoplasms under control. In line with this notion, enhancing T-cell functions by means of immune checkpoint inhibitors can tilt the balance toward tumor rejection.
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spelling pubmed-38502752013-12-06 Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells Liang, Hua Deng, Liufu Burnette, Byron Weichselbaum, Ralph R Fu, Yang-Xin Oncoimmunology Author's View Despite its efficacy and widespread use, radiation therapy is often associated with local or distal tumor relapse. We have recently found that CD8(+) T cells and their cytokines are essential for maintaining irradiated neoplasms under control. In line with this notion, enhancing T-cell functions by means of immune checkpoint inhibitors can tilt the balance toward tumor rejection. Landes Bioscience 2013-09-01 2013-07-09 /pmc/articles/PMC3850275/ /pubmed/24319637 http://dx.doi.org/10.4161/onci.25668 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Liang, Hua
Deng, Liufu
Burnette, Byron
Weichselbaum, Ralph R
Fu, Yang-Xin
Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells
title Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells
title_full Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells
title_fullStr Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells
title_full_unstemmed Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells
title_short Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells
title_sort radiation-induced tumor dormancy reflects an equilibrium between the proliferation and t lymphocyte-mediated death of malignant cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850275/
https://www.ncbi.nlm.nih.gov/pubmed/24319637
http://dx.doi.org/10.4161/onci.25668
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