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Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells
Despite its efficacy and widespread use, radiation therapy is often associated with local or distal tumor relapse. We have recently found that CD8(+) T cells and their cytokines are essential for maintaining irradiated neoplasms under control. In line with this notion, enhancing T-cell functions by...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850275/ https://www.ncbi.nlm.nih.gov/pubmed/24319637 http://dx.doi.org/10.4161/onci.25668 |
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author | Liang, Hua Deng, Liufu Burnette, Byron Weichselbaum, Ralph R Fu, Yang-Xin |
author_facet | Liang, Hua Deng, Liufu Burnette, Byron Weichselbaum, Ralph R Fu, Yang-Xin |
author_sort | Liang, Hua |
collection | PubMed |
description | Despite its efficacy and widespread use, radiation therapy is often associated with local or distal tumor relapse. We have recently found that CD8(+) T cells and their cytokines are essential for maintaining irradiated neoplasms under control. In line with this notion, enhancing T-cell functions by means of immune checkpoint inhibitors can tilt the balance toward tumor rejection. |
format | Online Article Text |
id | pubmed-3850275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-38502752013-12-06 Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells Liang, Hua Deng, Liufu Burnette, Byron Weichselbaum, Ralph R Fu, Yang-Xin Oncoimmunology Author's View Despite its efficacy and widespread use, radiation therapy is often associated with local or distal tumor relapse. We have recently found that CD8(+) T cells and their cytokines are essential for maintaining irradiated neoplasms under control. In line with this notion, enhancing T-cell functions by means of immune checkpoint inhibitors can tilt the balance toward tumor rejection. Landes Bioscience 2013-09-01 2013-07-09 /pmc/articles/PMC3850275/ /pubmed/24319637 http://dx.doi.org/10.4161/onci.25668 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Author's View Liang, Hua Deng, Liufu Burnette, Byron Weichselbaum, Ralph R Fu, Yang-Xin Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells |
title | Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells |
title_full | Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells |
title_fullStr | Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells |
title_full_unstemmed | Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells |
title_short | Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells |
title_sort | radiation-induced tumor dormancy reflects an equilibrium between the proliferation and t lymphocyte-mediated death of malignant cells |
topic | Author's View |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850275/ https://www.ncbi.nlm.nih.gov/pubmed/24319637 http://dx.doi.org/10.4161/onci.25668 |
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