Leptin modification in chronic myeloid leukemia patients treated with imatinib: An emerging effect of targeted therapy.()

We evaluated serum leptin levels in 9 young chronic myeloid leukemia (CML) patients under imatinib therapy during a long-term follow-up. Body mass index (BMI) and fat mass percentage (%FM) were also measured. Leptin was above the normal range in 8 out of 9 patients. In one case the hormone was below...

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Autores principales: Mariani, Stefania, Basciani, Sabrina, Giona, Fiorina, Lubrano, Carla, Ulisse, Salvatore, Gnessi, Lucio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850368/
https://www.ncbi.nlm.nih.gov/pubmed/24371782
http://dx.doi.org/10.1016/j.lrr.2013.07.001
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author Mariani, Stefania
Basciani, Sabrina
Giona, Fiorina
Lubrano, Carla
Ulisse, Salvatore
Gnessi, Lucio
author_facet Mariani, Stefania
Basciani, Sabrina
Giona, Fiorina
Lubrano, Carla
Ulisse, Salvatore
Gnessi, Lucio
author_sort Mariani, Stefania
collection PubMed
description We evaluated serum leptin levels in 9 young chronic myeloid leukemia (CML) patients under imatinib therapy during a long-term follow-up. Body mass index (BMI) and fat mass percentage (%FM) were also measured. Leptin was above the normal range in 8 out of 9 patients. In one case the hormone was below the reference value. All subjects showed a normal BMI, but 3 had a small increase of FM%. One patient recovered the leptin normal value after imatinib suspension. A tendency to leptin normalization in patients switched to an intermittent therapy was also found. This study suggests that imatinib therapy may result in leptin alteration.
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spelling pubmed-38503682013-12-26 Leptin modification in chronic myeloid leukemia patients treated with imatinib: An emerging effect of targeted therapy.() Mariani, Stefania Basciani, Sabrina Giona, Fiorina Lubrano, Carla Ulisse, Salvatore Gnessi, Lucio Leuk Res Rep Article We evaluated serum leptin levels in 9 young chronic myeloid leukemia (CML) patients under imatinib therapy during a long-term follow-up. Body mass index (BMI) and fat mass percentage (%FM) were also measured. Leptin was above the normal range in 8 out of 9 patients. In one case the hormone was below the reference value. All subjects showed a normal BMI, but 3 had a small increase of FM%. One patient recovered the leptin normal value after imatinib suspension. A tendency to leptin normalization in patients switched to an intermittent therapy was also found. This study suggests that imatinib therapy may result in leptin alteration. Elsevier 2013-08-08 /pmc/articles/PMC3850368/ /pubmed/24371782 http://dx.doi.org/10.1016/j.lrr.2013.07.001 Text en © 2013 The Authors http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Mariani, Stefania
Basciani, Sabrina
Giona, Fiorina
Lubrano, Carla
Ulisse, Salvatore
Gnessi, Lucio
Leptin modification in chronic myeloid leukemia patients treated with imatinib: An emerging effect of targeted therapy.()
title Leptin modification in chronic myeloid leukemia patients treated with imatinib: An emerging effect of targeted therapy.()
title_full Leptin modification in chronic myeloid leukemia patients treated with imatinib: An emerging effect of targeted therapy.()
title_fullStr Leptin modification in chronic myeloid leukemia patients treated with imatinib: An emerging effect of targeted therapy.()
title_full_unstemmed Leptin modification in chronic myeloid leukemia patients treated with imatinib: An emerging effect of targeted therapy.()
title_short Leptin modification in chronic myeloid leukemia patients treated with imatinib: An emerging effect of targeted therapy.()
title_sort leptin modification in chronic myeloid leukemia patients treated with imatinib: an emerging effect of targeted therapy.()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850368/
https://www.ncbi.nlm.nih.gov/pubmed/24371782
http://dx.doi.org/10.1016/j.lrr.2013.07.001
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