Rabbit antithymocyte globulin induces rapid expansion of effector memory CD8 T cells without accelerating acute graft versus host disease()

Rabbit antithymocyte globulin (Thymoglobulin(®)) is commonly used as graft-versus-host disease (GvHD) prophylaxis. Since we found similar total CD8 T cell numbers in patients with and without Thymoglobulin(®) therapy within the first six months after allogeneic hematopoietic stem cell transplantatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Wittenbecher, Friedrich, Rieger, Kathrin, Dziubianau, Mikalai, Herholz, Anne, Mensen, Angela, Blau, Igor Wolfgang, Uharek, Lutz, Dörken, Bernd, Thiel, Andreas, Na, Il-Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850384/
https://www.ncbi.nlm.nih.gov/pubmed/24371789
http://dx.doi.org/10.1016/j.lrr.2013.09.001
Descripción
Sumario:Rabbit antithymocyte globulin (Thymoglobulin(®)) is commonly used as graft-versus-host disease (GvHD) prophylaxis. Since we found similar total CD8 T cell numbers in patients with and without Thymoglobulin(®) therapy within the first six months after allogeneic hematopoietic stem cell transplantation, we have analyzed the reconstitution of the CD8 T cell compartment in detail. After T cell-depletion, higher and more sustained proliferative capacity of memory CD8 T cells resulted in their rapid expansion, whereas the fraction of naive CD8 T cells decreased. Importantly, this shift towards effector memory CD8 T cells did not accelerate the incidence of GvHD.

Ejemplares similares