Rabbit antithymocyte globulin induces rapid expansion of effector memory CD8 T cells without accelerating acute graft versus host disease()

Rabbit antithymocyte globulin (Thymoglobulin(®)) is commonly used as graft-versus-host disease (GvHD) prophylaxis. Since we found similar total CD8 T cell numbers in patients with and without Thymoglobulin(®) therapy within the first six months after allogeneic hematopoietic stem cell transplantatio...

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Autores principales: Wittenbecher, Friedrich, Rieger, Kathrin, Dziubianau, Mikalai, Herholz, Anne, Mensen, Angela, Blau, Igor Wolfgang, Uharek, Lutz, Dörken, Bernd, Thiel, Andreas, Na, Il-Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850384/
https://www.ncbi.nlm.nih.gov/pubmed/24371789
http://dx.doi.org/10.1016/j.lrr.2013.09.001
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author Wittenbecher, Friedrich
Rieger, Kathrin
Dziubianau, Mikalai
Herholz, Anne
Mensen, Angela
Blau, Igor Wolfgang
Uharek, Lutz
Dörken, Bernd
Thiel, Andreas
Na, Il-Kang
author_facet Wittenbecher, Friedrich
Rieger, Kathrin
Dziubianau, Mikalai
Herholz, Anne
Mensen, Angela
Blau, Igor Wolfgang
Uharek, Lutz
Dörken, Bernd
Thiel, Andreas
Na, Il-Kang
author_sort Wittenbecher, Friedrich
collection PubMed
description Rabbit antithymocyte globulin (Thymoglobulin(®)) is commonly used as graft-versus-host disease (GvHD) prophylaxis. Since we found similar total CD8 T cell numbers in patients with and without Thymoglobulin(®) therapy within the first six months after allogeneic hematopoietic stem cell transplantation, we have analyzed the reconstitution of the CD8 T cell compartment in detail. After T cell-depletion, higher and more sustained proliferative capacity of memory CD8 T cells resulted in their rapid expansion, whereas the fraction of naive CD8 T cells decreased. Importantly, this shift towards effector memory CD8 T cells did not accelerate the incidence of GvHD.
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spelling pubmed-38503842013-12-26 Rabbit antithymocyte globulin induces rapid expansion of effector memory CD8 T cells without accelerating acute graft versus host disease() Wittenbecher, Friedrich Rieger, Kathrin Dziubianau, Mikalai Herholz, Anne Mensen, Angela Blau, Igor Wolfgang Uharek, Lutz Dörken, Bernd Thiel, Andreas Na, Il-Kang Leuk Res Rep Brief Communication Rabbit antithymocyte globulin (Thymoglobulin(®)) is commonly used as graft-versus-host disease (GvHD) prophylaxis. Since we found similar total CD8 T cell numbers in patients with and without Thymoglobulin(®) therapy within the first six months after allogeneic hematopoietic stem cell transplantation, we have analyzed the reconstitution of the CD8 T cell compartment in detail. After T cell-depletion, higher and more sustained proliferative capacity of memory CD8 T cells resulted in their rapid expansion, whereas the fraction of naive CD8 T cells decreased. Importantly, this shift towards effector memory CD8 T cells did not accelerate the incidence of GvHD. Elsevier 2013-09-27 /pmc/articles/PMC3850384/ /pubmed/24371789 http://dx.doi.org/10.1016/j.lrr.2013.09.001 Text en © 2013 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Brief Communication
Wittenbecher, Friedrich
Rieger, Kathrin
Dziubianau, Mikalai
Herholz, Anne
Mensen, Angela
Blau, Igor Wolfgang
Uharek, Lutz
Dörken, Bernd
Thiel, Andreas
Na, Il-Kang
Rabbit antithymocyte globulin induces rapid expansion of effector memory CD8 T cells without accelerating acute graft versus host disease()
title Rabbit antithymocyte globulin induces rapid expansion of effector memory CD8 T cells without accelerating acute graft versus host disease()
title_full Rabbit antithymocyte globulin induces rapid expansion of effector memory CD8 T cells without accelerating acute graft versus host disease()
title_fullStr Rabbit antithymocyte globulin induces rapid expansion of effector memory CD8 T cells without accelerating acute graft versus host disease()
title_full_unstemmed Rabbit antithymocyte globulin induces rapid expansion of effector memory CD8 T cells without accelerating acute graft versus host disease()
title_short Rabbit antithymocyte globulin induces rapid expansion of effector memory CD8 T cells without accelerating acute graft versus host disease()
title_sort rabbit antithymocyte globulin induces rapid expansion of effector memory cd8 t cells without accelerating acute graft versus host disease()
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850384/
https://www.ncbi.nlm.nih.gov/pubmed/24371789
http://dx.doi.org/10.1016/j.lrr.2013.09.001
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