Prognostic impact of JAK2V617F mutation in myelodysplatic syndromes: A matched case control study()

While in RARS-T, JAK2V617F mutation is common and associated with good prognosis, the clinical and prognostic impact of this mutation in other MDS is unknown. We collected data from 132 non-RARS-T MDS with known JAK2V617F mutation status. JAK2V617F mutation was significantly correlated with lower pr...

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Autores principales: de Renzis, Benoit, Mansat-De Mas, Veronique, Wattel, Eric, Beyne-Rauzy, Odile, Knoops, Laurent, Cabrespine, Aurélie, Azgui, Zahia, Ades, Lionel, Kiladjian, Jean-Jacques, Fenaux, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850389/
https://www.ncbi.nlm.nih.gov/pubmed/24371784
http://dx.doi.org/10.1016/j.lrr.2013.06.003
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author de Renzis, Benoit
Mansat-De Mas, Veronique
Wattel, Eric
Beyne-Rauzy, Odile
Knoops, Laurent
Cabrespine, Aurélie
Azgui, Zahia
Ades, Lionel
Kiladjian, Jean-Jacques
Fenaux, Pierre
author_facet de Renzis, Benoit
Mansat-De Mas, Veronique
Wattel, Eric
Beyne-Rauzy, Odile
Knoops, Laurent
Cabrespine, Aurélie
Azgui, Zahia
Ades, Lionel
Kiladjian, Jean-Jacques
Fenaux, Pierre
author_sort de Renzis, Benoit
collection PubMed
description While in RARS-T, JAK2V617F mutation is common and associated with good prognosis, the clinical and prognostic impact of this mutation in other MDS is unknown. We collected data from 132 non-RARS-T MDS with known JAK2V617F mutation status. JAK2V617F mutation was significantly correlated with lower progression to AML (p<.0011) and better overall survival (OS, p=.011). OS difference persisted after matching on age, sex, IPSS and % marrow blast (p=.031). Thus, in MDS other than RARS-T, JAK2V617F mutation may be associated with favorable outcome.
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spelling pubmed-38503892013-12-26 Prognostic impact of JAK2V617F mutation in myelodysplatic syndromes: A matched case control study() de Renzis, Benoit Mansat-De Mas, Veronique Wattel, Eric Beyne-Rauzy, Odile Knoops, Laurent Cabrespine, Aurélie Azgui, Zahia Ades, Lionel Kiladjian, Jean-Jacques Fenaux, Pierre Leuk Res Rep Brief Communications While in RARS-T, JAK2V617F mutation is common and associated with good prognosis, the clinical and prognostic impact of this mutation in other MDS is unknown. We collected data from 132 non-RARS-T MDS with known JAK2V617F mutation status. JAK2V617F mutation was significantly correlated with lower progression to AML (p<.0011) and better overall survival (OS, p=.011). OS difference persisted after matching on age, sex, IPSS and % marrow blast (p=.031). Thus, in MDS other than RARS-T, JAK2V617F mutation may be associated with favorable outcome. Elsevier 2013-08-30 /pmc/articles/PMC3850389/ /pubmed/24371784 http://dx.doi.org/10.1016/j.lrr.2013.06.003 Text en © 2013 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Brief Communications
de Renzis, Benoit
Mansat-De Mas, Veronique
Wattel, Eric
Beyne-Rauzy, Odile
Knoops, Laurent
Cabrespine, Aurélie
Azgui, Zahia
Ades, Lionel
Kiladjian, Jean-Jacques
Fenaux, Pierre
Prognostic impact of JAK2V617F mutation in myelodysplatic syndromes: A matched case control study()
title Prognostic impact of JAK2V617F mutation in myelodysplatic syndromes: A matched case control study()
title_full Prognostic impact of JAK2V617F mutation in myelodysplatic syndromes: A matched case control study()
title_fullStr Prognostic impact of JAK2V617F mutation in myelodysplatic syndromes: A matched case control study()
title_full_unstemmed Prognostic impact of JAK2V617F mutation in myelodysplatic syndromes: A matched case control study()
title_short Prognostic impact of JAK2V617F mutation in myelodysplatic syndromes: A matched case control study()
title_sort prognostic impact of jak2v617f mutation in myelodysplatic syndromes: a matched case control study()
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850389/
https://www.ncbi.nlm.nih.gov/pubmed/24371784
http://dx.doi.org/10.1016/j.lrr.2013.06.003
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