Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice

BACKGROUND: Angiotensin-converting enzyme 2 (ACE2), a monocarboxypeptidase which metabolizes angiotensin II (Ang II) to generate Ang-(1–7), has been shown to prevent cardiac hypertrophy and injury but the mechanism remains elusive. Irbesartan has the dual actions of angiotensin receptor blockade and...

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Detalles Bibliográficos
Autores principales: Zhang, Zhen-Zhou, Shang, Qian-Hui, Jin, Hai-Yan, Song, Bei, Oudit, Gavin Y, Lu, Lin, Zhou, Tong, Xu, Ying-Le, Gao, Ping-Jin, Zhu, Ding-Liang, Penninger, Josef M, Zhong, Jiu-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850664/
https://www.ncbi.nlm.nih.gov/pubmed/24067190
http://dx.doi.org/10.1186/1479-5876-11-229

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