Tumour cells down-regulate CCN2 gene expression in co-cultured fibroblasts in a Smad7- and ERK-dependent manner

BACKGROUND: Recent studies have revealed that interactions between tumour cells and the surrounding stroma play an important role in facilitating tumour growth and invasion. Stromal fibroblasts produce most of the extracellular matrix components found in the stroma. The aim of this study was to inve...

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Detalles Bibliográficos
Autores principales: van Rooyen, Beverley A, Schäfer, Georgia, Leaner, Virna D, Parker, M Iqbal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850759/
https://www.ncbi.nlm.nih.gov/pubmed/24090133
http://dx.doi.org/10.1186/1478-811X-11-75

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850759/
https://www.ncbi.nlm.nih.gov/pubmed/24090133
http://dx.doi.org/10.1186/1478-811X-11-75

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