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Depression in Atrial Fibrillation in the General Population
BACKGROUND: Initial evidence suggests that depressive symptoms are more frequent in patients with atrial fibrillation. Data from the general population are limited. METHODS AND RESULTS: In 10,000 individuals (mean age 56±11 years, 49.4% women) of the population-based Gutenberg Health Study we assess...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850915/ https://www.ncbi.nlm.nih.gov/pubmed/24324579 http://dx.doi.org/10.1371/journal.pone.0079109 |
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author | Schnabel, Renate B. Michal, Matthias Wilde, Sandra Wiltink, Jörg Wild, Philipp S. Sinning, Christoph R. Lubos, Edith Ojeda, Francisco M. Zeller, Tanja Munzel, Thomas Blankenberg, Stefan Beutel, Manfred E. |
author_facet | Schnabel, Renate B. Michal, Matthias Wilde, Sandra Wiltink, Jörg Wild, Philipp S. Sinning, Christoph R. Lubos, Edith Ojeda, Francisco M. Zeller, Tanja Munzel, Thomas Blankenberg, Stefan Beutel, Manfred E. |
author_sort | Schnabel, Renate B. |
collection | PubMed |
description | BACKGROUND: Initial evidence suggests that depressive symptoms are more frequent in patients with atrial fibrillation. Data from the general population are limited. METHODS AND RESULTS: In 10,000 individuals (mean age 56±11 years, 49.4% women) of the population-based Gutenberg Health Study we assessed depression by the Patient Health Questionnaire (PHQ-9) and a history of depression in relation to manifest atrial fibrillation (n = 309 cases). The median (25th/75th percentile) PHQ-9 score of depressive symptoms was 4 (2/6) in atrial fibrillation individuals versus 3 (2/6) individuals without atrial fibrillation, [Image: see text]. Multivariable regression analyses of the severity of depressive symptoms in relation to atrial fibrillation in cardiovascular risk factor adjusted models revealed a relation of PHQ-9 values and atrial fibrillation (odds ratio (OR) 1.04, 95% confidence interval (CI) 1.01–1.08; P = 0.023). The association was stronger for the somatic symptom dimension of depression (OR 1.08, 95% CI 1.02–1.15; P = 0.0085) than for cognitive symptoms (OR 1.05, 95% CI 0.98–1.11; P = 0.15). Results did not change markedly after additional adjustment for heart failure, partnership status or the inflammatory biomarker C-reactive protein. Both, self-reported physical health status, very good/good versus fair/bad, (OR 0.54, 95% CI 0.41–0.70; P<0.001) and mental health status (OR 0.61 (0.46–0.82); P = 0.0012) were associated with atrial fibrillation in multivariable-adjusted models. CONCLUSIONS: In a population-based sample we observed a higher burden of depressive symptoms driven by somatic symptom dimensions in individuals with atrial fibrillation. Depression was associated with a worse perception of physical or mental health status. Whether screening and treatment of depressive symptoms modulates disease progression and outcome needs to be shown. |
format | Online Article Text |
id | pubmed-3850915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38509152013-12-09 Depression in Atrial Fibrillation in the General Population Schnabel, Renate B. Michal, Matthias Wilde, Sandra Wiltink, Jörg Wild, Philipp S. Sinning, Christoph R. Lubos, Edith Ojeda, Francisco M. Zeller, Tanja Munzel, Thomas Blankenberg, Stefan Beutel, Manfred E. PLoS One Research Article BACKGROUND: Initial evidence suggests that depressive symptoms are more frequent in patients with atrial fibrillation. Data from the general population are limited. METHODS AND RESULTS: In 10,000 individuals (mean age 56±11 years, 49.4% women) of the population-based Gutenberg Health Study we assessed depression by the Patient Health Questionnaire (PHQ-9) and a history of depression in relation to manifest atrial fibrillation (n = 309 cases). The median (25th/75th percentile) PHQ-9 score of depressive symptoms was 4 (2/6) in atrial fibrillation individuals versus 3 (2/6) individuals without atrial fibrillation, [Image: see text]. Multivariable regression analyses of the severity of depressive symptoms in relation to atrial fibrillation in cardiovascular risk factor adjusted models revealed a relation of PHQ-9 values and atrial fibrillation (odds ratio (OR) 1.04, 95% confidence interval (CI) 1.01–1.08; P = 0.023). The association was stronger for the somatic symptom dimension of depression (OR 1.08, 95% CI 1.02–1.15; P = 0.0085) than for cognitive symptoms (OR 1.05, 95% CI 0.98–1.11; P = 0.15). Results did not change markedly after additional adjustment for heart failure, partnership status or the inflammatory biomarker C-reactive protein. Both, self-reported physical health status, very good/good versus fair/bad, (OR 0.54, 95% CI 0.41–0.70; P<0.001) and mental health status (OR 0.61 (0.46–0.82); P = 0.0012) were associated with atrial fibrillation in multivariable-adjusted models. CONCLUSIONS: In a population-based sample we observed a higher burden of depressive symptoms driven by somatic symptom dimensions in individuals with atrial fibrillation. Depression was associated with a worse perception of physical or mental health status. Whether screening and treatment of depressive symptoms modulates disease progression and outcome needs to be shown. Public Library of Science 2013-12-04 /pmc/articles/PMC3850915/ /pubmed/24324579 http://dx.doi.org/10.1371/journal.pone.0079109 Text en © 2013 Schnabel et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Schnabel, Renate B. Michal, Matthias Wilde, Sandra Wiltink, Jörg Wild, Philipp S. Sinning, Christoph R. Lubos, Edith Ojeda, Francisco M. Zeller, Tanja Munzel, Thomas Blankenberg, Stefan Beutel, Manfred E. Depression in Atrial Fibrillation in the General Population |
title | Depression in Atrial Fibrillation in the General Population |
title_full | Depression in Atrial Fibrillation in the General Population |
title_fullStr | Depression in Atrial Fibrillation in the General Population |
title_full_unstemmed | Depression in Atrial Fibrillation in the General Population |
title_short | Depression in Atrial Fibrillation in the General Population |
title_sort | depression in atrial fibrillation in the general population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850915/ https://www.ncbi.nlm.nih.gov/pubmed/24324579 http://dx.doi.org/10.1371/journal.pone.0079109 |
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