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Early postoperative administration of probiotics versus placebo in elderly patients undergoing elective colorectal surgery: a double-blind randomized controlled trial

BACKGROUND: Perioperative prophylactic antibiotic treatment significantly influences intestinal microflora, resulting in impaired bowel functioning in some patients, sometimes requiring further investigations. This may lead to a worse health-related quality of life (HRQoL). Probiotics administrated...

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Autores principales: Pellino, Gianluca, Sciaudone, Guido, Candilio, Giuseppe, Camerlingo, Antonio, Marcellinaro, Rosa, De Fatico, Serena, Rocco, Federica, Canonico, Silvestro, Riegler, Gabriele, Selvaggi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850968/
https://www.ncbi.nlm.nih.gov/pubmed/24268034
http://dx.doi.org/10.1186/1471-2482-13-S2-S57
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author Pellino, Gianluca
Sciaudone, Guido
Candilio, Giuseppe
Camerlingo, Antonio
Marcellinaro, Rosa
De Fatico, Serena
Rocco, Federica
Canonico, Silvestro
Riegler, Gabriele
Selvaggi, Francesco
author_facet Pellino, Gianluca
Sciaudone, Guido
Candilio, Giuseppe
Camerlingo, Antonio
Marcellinaro, Rosa
De Fatico, Serena
Rocco, Federica
Canonico, Silvestro
Riegler, Gabriele
Selvaggi, Francesco
author_sort Pellino, Gianluca
collection PubMed
description BACKGROUND: Perioperative prophylactic antibiotic treatment significantly influences intestinal microflora, resulting in impaired bowel functioning in some patients, sometimes requiring further investigations. This may lead to a worse health-related quality of life (HRQoL). Probiotics administrated in the early post-operative period may help avoiding such nuisances in older people. METHODS: We prospectively enrolled patients undergoing laparoscopic colorectal surgery aged over 70 years between 2005 and 2012. The study was approved by IRB. All patients received perioperative antibiotic treatment. Patients were randomized to one of two treatment arms: Group A patients received probiotics after surgery (VSL#3, VSL Pharmaceuticals, Inc. USA - 900 × 10(9 )daily, while Group B patients received a Placebo (cornstarch). Patients were further divided in sub-groups whether ileo-caecal valve was spared or not. Patients were followed-up every 7 days for 4 weeks. Patients daily annotated bowel frequency, stool shape and consistency - according to Bristol's scale. HRQoL was assessed every week by means of SF-36 questionnaire. RESULTS: Group A included 10 while Group B included 8 patients. One patient in each group experienced a postoperative complication. Group A patients had fewer bowel movements than controls, during every week. Stool consistency was higher in patients undergoing resections including ileo-caecal valve receiving VSL#3. HRQoL gradually increased in both groups; Group A patients had higher "social functioning" item scores at week 1 and 4 than controls. CONCLUSIONS: Elderly patients undergoing resection of ileo-caecal valve may benefit from an early probiotics administration pathway after perioperative antibiotic treatment.
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spelling pubmed-38509682013-12-13 Early postoperative administration of probiotics versus placebo in elderly patients undergoing elective colorectal surgery: a double-blind randomized controlled trial Pellino, Gianluca Sciaudone, Guido Candilio, Giuseppe Camerlingo, Antonio Marcellinaro, Rosa De Fatico, Serena Rocco, Federica Canonico, Silvestro Riegler, Gabriele Selvaggi, Francesco BMC Surg Research Article BACKGROUND: Perioperative prophylactic antibiotic treatment significantly influences intestinal microflora, resulting in impaired bowel functioning in some patients, sometimes requiring further investigations. This may lead to a worse health-related quality of life (HRQoL). Probiotics administrated in the early post-operative period may help avoiding such nuisances in older people. METHODS: We prospectively enrolled patients undergoing laparoscopic colorectal surgery aged over 70 years between 2005 and 2012. The study was approved by IRB. All patients received perioperative antibiotic treatment. Patients were randomized to one of two treatment arms: Group A patients received probiotics after surgery (VSL#3, VSL Pharmaceuticals, Inc. USA - 900 × 10(9 )daily, while Group B patients received a Placebo (cornstarch). Patients were further divided in sub-groups whether ileo-caecal valve was spared or not. Patients were followed-up every 7 days for 4 weeks. Patients daily annotated bowel frequency, stool shape and consistency - according to Bristol's scale. HRQoL was assessed every week by means of SF-36 questionnaire. RESULTS: Group A included 10 while Group B included 8 patients. One patient in each group experienced a postoperative complication. Group A patients had fewer bowel movements than controls, during every week. Stool consistency was higher in patients undergoing resections including ileo-caecal valve receiving VSL#3. HRQoL gradually increased in both groups; Group A patients had higher "social functioning" item scores at week 1 and 4 than controls. CONCLUSIONS: Elderly patients undergoing resection of ileo-caecal valve may benefit from an early probiotics administration pathway after perioperative antibiotic treatment. BioMed Central 2013-10-08 /pmc/articles/PMC3850968/ /pubmed/24268034 http://dx.doi.org/10.1186/1471-2482-13-S2-S57 Text en Copyright © 2013 Pellino et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Pellino, Gianluca
Sciaudone, Guido
Candilio, Giuseppe
Camerlingo, Antonio
Marcellinaro, Rosa
De Fatico, Serena
Rocco, Federica
Canonico, Silvestro
Riegler, Gabriele
Selvaggi, Francesco
Early postoperative administration of probiotics versus placebo in elderly patients undergoing elective colorectal surgery: a double-blind randomized controlled trial
title Early postoperative administration of probiotics versus placebo in elderly patients undergoing elective colorectal surgery: a double-blind randomized controlled trial
title_full Early postoperative administration of probiotics versus placebo in elderly patients undergoing elective colorectal surgery: a double-blind randomized controlled trial
title_fullStr Early postoperative administration of probiotics versus placebo in elderly patients undergoing elective colorectal surgery: a double-blind randomized controlled trial
title_full_unstemmed Early postoperative administration of probiotics versus placebo in elderly patients undergoing elective colorectal surgery: a double-blind randomized controlled trial
title_short Early postoperative administration of probiotics versus placebo in elderly patients undergoing elective colorectal surgery: a double-blind randomized controlled trial
title_sort early postoperative administration of probiotics versus placebo in elderly patients undergoing elective colorectal surgery: a double-blind randomized controlled trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850968/
https://www.ncbi.nlm.nih.gov/pubmed/24268034
http://dx.doi.org/10.1186/1471-2482-13-S2-S57
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