Implication of HLA-DMA Alleles in Corsican IDDM

The HLA-DM molecule catalyses the CLIP/antigen peptide exchange in the classical class II peptide-binding groove. As such, DM is an antigen presentation regulator and may be linked to autoimmune diseases. Using PCR derived methods, a relationship was revealed between DM gene polymorphism and IDDM, i...

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Detalles Bibliográficos
Autores principales: Cucchi-Mouillot, P., Lai, S., Carcassi, C., Sorba, P., Stuart-Simoni, M., Amoros, J.-P., Genetet, B., Haras, D., Contu, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 1998
Materias:
Other
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851055/
https://www.ncbi.nlm.nih.gov/pubmed/10427471
http://dx.doi.org/10.1155/1998/705857
Descripción
Sumario:The HLA-DM molecule catalyses the CLIP/antigen peptide exchange in the classical class II peptide-binding groove. As such, DM is an antigen presentation regulator and may be linked to autoimmune diseases. Using PCR derived methods, a relationship was revealed between DM gene polymorphism and IDDM, in a Corsican population. The DMA*0101 allele was observed to confer a significant predisposition to this autoimmune disease while the DMA*0102 allele protected significantly. Experiments examining polymorphism of the HLA-DRB1 gene established that these relationships are not a consequence of linkage disequilibrium with HLA-DRB1 alleles implicated in this pathology. The study of the DMA gene could therefore be an additional tool for early IDDM diagnosis in the Corsican population.

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