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The Significance of PSA/IGF-1 Ratio in Differentiating Benign Prostate Hyperplasia from Prostate Cancer

The importance of insulin-like growth factor 1 (IGF-1) in human serum for the early diagnosis of prostate cancer is controversial. The IGF-1/PSA ratio may improve the performance of prostate specific antigen (PSA) as a prostate cancer marker. IGF-1, along with PSA and free PSA concentration, was mea...

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Autores principales: Koliakos, G., Chatzivasiliou, D., Dimopoulos, Th., Trachana, V., Paschalidou, K., Galiamoutsas, V., Triantos, A., Chitas, G., Dimopoulos, A., Vlatsas, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851088/
https://www.ncbi.nlm.nih.gov/pubmed/11381196
http://dx.doi.org/10.1155/2000/764851
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author Koliakos, G.
Chatzivasiliou, D.
Dimopoulos, Th.
Trachana, V.
Paschalidou, K.
Galiamoutsas, V.
Triantos, A.
Chitas, G.
Dimopoulos, A.
Vlatsas, G.
author_facet Koliakos, G.
Chatzivasiliou, D.
Dimopoulos, Th.
Trachana, V.
Paschalidou, K.
Galiamoutsas, V.
Triantos, A.
Chitas, G.
Dimopoulos, A.
Vlatsas, G.
author_sort Koliakos, G.
collection PubMed
description The importance of insulin-like growth factor 1 (IGF-1) in human serum for the early diagnosis of prostate cancer is controversial. The IGF-1/PSA ratio may improve the performance of prostate specific antigen (PSA) as a prostate cancer marker. IGF-1, along with PSA and free PSA concentration, was measured in the serum of 34 patients with prostate cancer and in 131 patients with benign prostatic hyperplasia (BPH). Although IGF-1 concentration did not significantly differ between the groups, PSA/IGF-1 ratio could clearly distinguish the two groups. In patients with cancer but not in patients with BPH, IGF-1 concentration correlated with PSA and free PSA. The values of PSA and free PSA correlated with each other for both groups. Receivers Operating Curve (ROC) analysis indicated a better sensitivity to specificity ratio for PSA/IGF-1 than for PSA or Free/Total (F/T) PSA.
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spelling pubmed-38510882013-12-12 The Significance of PSA/IGF-1 Ratio in Differentiating Benign Prostate Hyperplasia from Prostate Cancer Koliakos, G. Chatzivasiliou, D. Dimopoulos, Th. Trachana, V. Paschalidou, K. Galiamoutsas, V. Triantos, A. Chitas, G. Dimopoulos, A. Vlatsas, G. Dis Markers Other The importance of insulin-like growth factor 1 (IGF-1) in human serum for the early diagnosis of prostate cancer is controversial. The IGF-1/PSA ratio may improve the performance of prostate specific antigen (PSA) as a prostate cancer marker. IGF-1, along with PSA and free PSA concentration, was measured in the serum of 34 patients with prostate cancer and in 131 patients with benign prostatic hyperplasia (BPH). Although IGF-1 concentration did not significantly differ between the groups, PSA/IGF-1 ratio could clearly distinguish the two groups. In patients with cancer but not in patients with BPH, IGF-1 concentration correlated with PSA and free PSA. The values of PSA and free PSA correlated with each other for both groups. Receivers Operating Curve (ROC) analysis indicated a better sensitivity to specificity ratio for PSA/IGF-1 than for PSA or Free/Total (F/T) PSA. IOS Press 2000 2002-06-07 /pmc/articles/PMC3851088/ /pubmed/11381196 http://dx.doi.org/10.1155/2000/764851 Text en Copyright © 2000 Hindawi Publishing Corporation.
spellingShingle Other
Koliakos, G.
Chatzivasiliou, D.
Dimopoulos, Th.
Trachana, V.
Paschalidou, K.
Galiamoutsas, V.
Triantos, A.
Chitas, G.
Dimopoulos, A.
Vlatsas, G.
The Significance of PSA/IGF-1 Ratio in Differentiating Benign Prostate Hyperplasia from Prostate Cancer
title The Significance of PSA/IGF-1 Ratio in Differentiating Benign Prostate Hyperplasia from Prostate Cancer
title_full The Significance of PSA/IGF-1 Ratio in Differentiating Benign Prostate Hyperplasia from Prostate Cancer
title_fullStr The Significance of PSA/IGF-1 Ratio in Differentiating Benign Prostate Hyperplasia from Prostate Cancer
title_full_unstemmed The Significance of PSA/IGF-1 Ratio in Differentiating Benign Prostate Hyperplasia from Prostate Cancer
title_short The Significance of PSA/IGF-1 Ratio in Differentiating Benign Prostate Hyperplasia from Prostate Cancer
title_sort significance of psa/igf-1 ratio in differentiating benign prostate hyperplasia from prostate cancer
topic Other
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851088/
https://www.ncbi.nlm.nih.gov/pubmed/11381196
http://dx.doi.org/10.1155/2000/764851
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