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Surfactant Protein B Intron 4 Variation in German Patients with COPD and Acute Respiratory Failure
Chronic obstructive pulmonary disease (COPD) is a major health problem. Genetic factors that contribute to the disease have been postulated. The pulmonary surfactant protein B (SP-B), which is essential for normal lung function, is considered as a candidate gene for COPD in this case-control study....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2002
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851100/ https://www.ncbi.nlm.nih.gov/pubmed/12515908 http://dx.doi.org/10.1155/2002/194075 |
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author | Seifart, Carola Plagens, Alexandra Brödje, Dörte Müller, Bernd von Wichert, Peter Floros, Joanna |
author_facet | Seifart, Carola Plagens, Alexandra Brödje, Dörte Müller, Bernd von Wichert, Peter Floros, Joanna |
author_sort | Seifart, Carola |
collection | PubMed |
description | Chronic obstructive pulmonary disease (COPD) is a major health problem. Genetic factors that contribute to the disease have been postulated. The pulmonary surfactant protein B (SP-B), which is essential for normal lung function, is considered as a candidate gene for COPD in this case-control study. We studied the SP-B intron 4 size variants in 346 individuals. This group consisted of 118 patients with chronic bronchitis or COPD, including 24 patients with acute respiratory failure (ARF) in COPD, 118 matched controls without pulmonary disease and 110 healthy individuals (population control). The frequency of intron 4 variants was similar in either control group (10.9%, 14.4% respectively), with a small increase in the COPD group (18.6%). This increase was due to a high increase of intron 4 variants in the ARF subgroup (37.5%, p = 0.003, OR 4.9, 95% CI: 1.76–13.6). The data indicate that SP-B intron 4 variants may associate with increased risk of ARF in COPD and may be used as a marker of susceptibility in this disease subgroup. |
format | Online Article Text |
id | pubmed-3851100 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38511002013-12-25 Surfactant Protein B Intron 4 Variation in German Patients with COPD and Acute Respiratory Failure Seifart, Carola Plagens, Alexandra Brödje, Dörte Müller, Bernd von Wichert, Peter Floros, Joanna Dis Markers Other Chronic obstructive pulmonary disease (COPD) is a major health problem. Genetic factors that contribute to the disease have been postulated. The pulmonary surfactant protein B (SP-B), which is essential for normal lung function, is considered as a candidate gene for COPD in this case-control study. We studied the SP-B intron 4 size variants in 346 individuals. This group consisted of 118 patients with chronic bronchitis or COPD, including 24 patients with acute respiratory failure (ARF) in COPD, 118 matched controls without pulmonary disease and 110 healthy individuals (population control). The frequency of intron 4 variants was similar in either control group (10.9%, 14.4% respectively), with a small increase in the COPD group (18.6%). This increase was due to a high increase of intron 4 variants in the ARF subgroup (37.5%, p = 0.003, OR 4.9, 95% CI: 1.76–13.6). The data indicate that SP-B intron 4 variants may associate with increased risk of ARF in COPD and may be used as a marker of susceptibility in this disease subgroup. IOS Press 2002 2002-12-04 /pmc/articles/PMC3851100/ /pubmed/12515908 http://dx.doi.org/10.1155/2002/194075 Text en Copyright © 2002 Hindawi Publishing Corporation. |
spellingShingle | Other Seifart, Carola Plagens, Alexandra Brödje, Dörte Müller, Bernd von Wichert, Peter Floros, Joanna Surfactant Protein B Intron 4 Variation in German Patients with COPD and Acute Respiratory Failure |
title | Surfactant Protein B Intron 4 Variation in German Patients with COPD and Acute Respiratory Failure |
title_full | Surfactant Protein B Intron 4 Variation in German Patients with COPD and Acute Respiratory Failure |
title_fullStr | Surfactant Protein B Intron 4 Variation in German Patients with COPD and Acute Respiratory Failure |
title_full_unstemmed | Surfactant Protein B Intron 4 Variation in German Patients with COPD and Acute Respiratory Failure |
title_short | Surfactant Protein B Intron 4 Variation in German Patients with COPD and Acute Respiratory Failure |
title_sort | surfactant protein b intron 4 variation in german patients with copd and acute respiratory failure |
topic | Other |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851100/ https://www.ncbi.nlm.nih.gov/pubmed/12515908 http://dx.doi.org/10.1155/2002/194075 |
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