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LC-MS characterization and purity assessment of a prototype bispecific antibody

Bispecific IgG asymmetric (heterodimeric) antibodies offer enhanced therapeutic efficacy, but present unique challenges for drug development. These challenges are related to the proper assembly of heavy and light chains. Impurities such as symmetric (homodimeric) antibodies can arise with improper a...

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Detalles Bibliográficos
Autores principales:	Woods, R. Jeremy, Xie, Michael Hongwei, Von Kreudenstein, Thomas Spreter, Ng, Gordon Y., Dixit, Surjit B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2013
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851224/ https://www.ncbi.nlm.nih.gov/pubmed/23884083 http://dx.doi.org/10.4161/mabs.25488

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