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Purification of monoclonal antibodies by hydrophobic interaction chromatography under no-salt conditions
Hydrophobic interaction chromatography (HIC) is commonly used as a polishing step in monoclonal antibody purification processes. HIC offers an orthogonal selectivity to ion exchange chromatography and can be an effective step for aggregate clearance and host cell protein reduction. HIC, however, suf...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851231/ https://www.ncbi.nlm.nih.gov/pubmed/23884181 http://dx.doi.org/10.4161/mabs.25552 |