Evidence for an Association between the SRD5A2 (Type II Steroid 5α-Reductase) Locus and Prostate Cancer in Italian Patients

We have investigated the contributions of three polymorphic markers in the SRD5A2 gene to prostate cancer in a group of Italian patients. We have genotyped cases and controls for a polymorphic (TA)(n) dinucleotide repeat and two functional substitutions, A49T and V89L, substituting respectively alan...

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Detalles Bibliográficos
Autores principales: Margiotti, K., Sangiuolo, F., De Luca, A., Froio, F., Pearce, C. L., Ricci-Barbini, V., Micali, F., Bonafè, M., Franceschi, C., Dallapiccola, B., Novelli, G., Reichardt, J. K. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2000
Materias:
Other
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851368/
https://www.ncbi.nlm.nih.gov/pubmed/11381197
http://dx.doi.org/10.1155/2000/683607
Descripción
Sumario:We have investigated the contributions of three polymorphic markers in the SRD5A2 gene to prostate cancer in a group of Italian patients. We have genotyped cases and controls for a polymorphic (TA)(n) dinucleotide repeat and two functional substitutions, A49T and V89L, substituting respectively alanine with threonine at codon 49, and valine to leucine at codon 89. We found a substantially increased but not significant risk associated with the 49T mutation and a reduction of risk for the V89L substitution. In conclusion, we report on preliminary evidence for both increased and decreased risk associated with separate markers at this locus.

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