Evidence for an Association between the SRD5A2 (Type II Steroid 5α-Reductase) Locus and Prostate Cancer in Italian Patients

We have investigated the contributions of three polymorphic markers in the SRD5A2 gene to prostate cancer in a group of Italian patients. We have genotyped cases and controls for a polymorphic (TA)(n) dinucleotide repeat and two functional substitutions, A49T and V89L, substituting respectively alan...

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Autores principales: Margiotti, K., Sangiuolo, F., De Luca, A., Froio, F., Pearce, C. L., Ricci-Barbini, V., Micali, F., Bonafè, M., Franceschi, C., Dallapiccola, B., Novelli, G., Reichardt, J. K. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2000
Materias:
Other
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851368/
https://www.ncbi.nlm.nih.gov/pubmed/11381197
http://dx.doi.org/10.1155/2000/683607
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author Margiotti, K.
Sangiuolo, F.
De Luca, A.
Froio, F.
Pearce, C. L.
Ricci-Barbini, V.
Micali, F.
Bonafè, M.
Franceschi, C.
Dallapiccola, B.
Novelli, G.
Reichardt, J. K. V.
author_facet Margiotti, K.
Sangiuolo, F.
De Luca, A.
Froio, F.
Pearce, C. L.
Ricci-Barbini, V.
Micali, F.
Bonafè, M.
Franceschi, C.
Dallapiccola, B.
Novelli, G.
Reichardt, J. K. V.
author_sort Margiotti, K.
collection PubMed
description We have investigated the contributions of three polymorphic markers in the SRD5A2 gene to prostate cancer in a group of Italian patients. We have genotyped cases and controls for a polymorphic (TA)(n) dinucleotide repeat and two functional substitutions, A49T and V89L, substituting respectively alanine with threonine at codon 49, and valine to leucine at codon 89. We found a substantially increased but not significant risk associated with the 49T mutation and a reduction of risk for the V89L substitution. In conclusion, we report on preliminary evidence for both increased and decreased risk associated with separate markers at this locus.
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spelling pubmed-38513682013-12-12 Evidence for an Association between the SRD5A2 (Type II Steroid 5α-Reductase) Locus and Prostate Cancer in Italian Patients Margiotti, K. Sangiuolo, F. De Luca, A. Froio, F. Pearce, C. L. Ricci-Barbini, V. Micali, F. Bonafè, M. Franceschi, C. Dallapiccola, B. Novelli, G. Reichardt, J. K. V. Dis Markers Other We have investigated the contributions of three polymorphic markers in the SRD5A2 gene to prostate cancer in a group of Italian patients. We have genotyped cases and controls for a polymorphic (TA)(n) dinucleotide repeat and two functional substitutions, A49T and V89L, substituting respectively alanine with threonine at codon 49, and valine to leucine at codon 89. We found a substantially increased but not significant risk associated with the 49T mutation and a reduction of risk for the V89L substitution. In conclusion, we report on preliminary evidence for both increased and decreased risk associated with separate markers at this locus. IOS Press 2000 2002-06-07 /pmc/articles/PMC3851368/ /pubmed/11381197 http://dx.doi.org/10.1155/2000/683607 Text en Copyright © 2000 Hindawi Publishing Corporation.
spellingShingle Other
Margiotti, K.
Sangiuolo, F.
De Luca, A.
Froio, F.
Pearce, C. L.
Ricci-Barbini, V.
Micali, F.
Bonafè, M.
Franceschi, C.
Dallapiccola, B.
Novelli, G.
Reichardt, J. K. V.
Evidence for an Association between the SRD5A2 (Type II Steroid 5α-Reductase) Locus and Prostate Cancer in Italian Patients
title Evidence for an Association between the SRD5A2 (Type II Steroid 5α-Reductase) Locus and Prostate Cancer in Italian Patients
title_full Evidence for an Association between the SRD5A2 (Type II Steroid 5α-Reductase) Locus and Prostate Cancer in Italian Patients
title_fullStr Evidence for an Association between the SRD5A2 (Type II Steroid 5α-Reductase) Locus and Prostate Cancer in Italian Patients
title_full_unstemmed Evidence for an Association between the SRD5A2 (Type II Steroid 5α-Reductase) Locus and Prostate Cancer in Italian Patients
title_short Evidence for an Association between the SRD5A2 (Type II Steroid 5α-Reductase) Locus and Prostate Cancer in Italian Patients
title_sort evidence for an association between the srd5a2 (type ii steroid 5α-reductase) locus and prostate cancer in italian patients
topic Other
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851368/
https://www.ncbi.nlm.nih.gov/pubmed/11381197
http://dx.doi.org/10.1155/2000/683607
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