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Non Classical HLA Genes and Non-HLA Genes in a Population of Infants at Familial Risk of Atopy

Aim: We investigated on parental history and IgE serum level in 2588 consecutive newborns to individuate babies “at risk” of atopy at birth and we analysed the polymorphisms of class III region to evaluate the association with immunogenetic markers of HLA: C4A, C4B, LTA, RAGE and TNFA genes; we perf...

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Autores principales: De Silvestri, A., Belloni, C., De Amici, M., Mazzola, P., Zorzetto, M., Martinetti, M., Salvaneschi, L., Cuccia, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851371/
https://www.ncbi.nlm.nih.gov/pubmed/16788244
http://dx.doi.org/10.1155/2006/321798
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author De Silvestri, A.
Belloni, C.
De Amici, M.
Mazzola, P.
Zorzetto, M.
Martinetti, M.
Salvaneschi, L.
Cuccia, M.
author_facet De Silvestri, A.
Belloni, C.
De Amici, M.
Mazzola, P.
Zorzetto, M.
Martinetti, M.
Salvaneschi, L.
Cuccia, M.
author_sort De Silvestri, A.
collection PubMed
description Aim: We investigated on parental history and IgE serum level in 2588 consecutive newborns to individuate babies “at risk” of atopy at birth and we analysed the polymorphisms of class III region to evaluate the association with immunogenetic markers of HLA: C4A, C4B, LTA, RAGE and TNFA genes; we performed TNF and IgE receptor (FCERB1) physiologically related gene polymorphisms. Result: 791 babies/2588 (30.6%) were considered “at risk” for atopy and followed-up: 400 had familial history of atopy (at least one parent or sibling), 256 had IgE > 0.35 kUA/l at birth and during the follow-up and 135 were positive for both conditions. The allele C4B2 was significantly more frequent in the sample of babies at risk (22.1% vs 10%, p < 0.001). Furthermore, the mean value of IgE at birth in babies carrying the allele C4B2 was 2.26 KUA/l versus 0.74 KUA/l in those not carrying this allele (p = 0.01). No significant association emerged for RAGE at the centromeric end of class III region and for LTA, TNFA at the telomeric one. TNFRI, TNFRII and FCERB1 gene polymorphisms also seemed not implicated. Conclusion: Our study confirms that HLA class III region seems involved in familial predisposition to atopy, and C4B gene probably acts as a marker of a more restricted subregion.
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spelling pubmed-38513712013-12-18 Non Classical HLA Genes and Non-HLA Genes in a Population of Infants at Familial Risk of Atopy De Silvestri, A. Belloni, C. De Amici, M. Mazzola, P. Zorzetto, M. Martinetti, M. Salvaneschi, L. Cuccia, M. Dis Markers Other Aim: We investigated on parental history and IgE serum level in 2588 consecutive newborns to individuate babies “at risk” of atopy at birth and we analysed the polymorphisms of class III region to evaluate the association with immunogenetic markers of HLA: C4A, C4B, LTA, RAGE and TNFA genes; we performed TNF and IgE receptor (FCERB1) physiologically related gene polymorphisms. Result: 791 babies/2588 (30.6%) were considered “at risk” for atopy and followed-up: 400 had familial history of atopy (at least one parent or sibling), 256 had IgE > 0.35 kUA/l at birth and during the follow-up and 135 were positive for both conditions. The allele C4B2 was significantly more frequent in the sample of babies at risk (22.1% vs 10%, p < 0.001). Furthermore, the mean value of IgE at birth in babies carrying the allele C4B2 was 2.26 KUA/l versus 0.74 KUA/l in those not carrying this allele (p = 0.01). No significant association emerged for RAGE at the centromeric end of class III region and for LTA, TNFA at the telomeric one. TNFRI, TNFRII and FCERB1 gene polymorphisms also seemed not implicated. Conclusion: Our study confirms that HLA class III region seems involved in familial predisposition to atopy, and C4B gene probably acts as a marker of a more restricted subregion. IOS Press 2006 2006-06-15 /pmc/articles/PMC3851371/ /pubmed/16788244 http://dx.doi.org/10.1155/2006/321798 Text en Copyright © 2006 Hindawi Publishing Corporation.
spellingShingle Other
De Silvestri, A.
Belloni, C.
De Amici, M.
Mazzola, P.
Zorzetto, M.
Martinetti, M.
Salvaneschi, L.
Cuccia, M.
Non Classical HLA Genes and Non-HLA Genes in a Population of Infants at Familial Risk of Atopy
title Non Classical HLA Genes and Non-HLA Genes in a Population of Infants at Familial Risk of Atopy
title_full Non Classical HLA Genes and Non-HLA Genes in a Population of Infants at Familial Risk of Atopy
title_fullStr Non Classical HLA Genes and Non-HLA Genes in a Population of Infants at Familial Risk of Atopy
title_full_unstemmed Non Classical HLA Genes and Non-HLA Genes in a Population of Infants at Familial Risk of Atopy
title_short Non Classical HLA Genes and Non-HLA Genes in a Population of Infants at Familial Risk of Atopy
title_sort non classical hla genes and non-hla genes in a population of infants at familial risk of atopy
topic Other
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851371/
https://www.ncbi.nlm.nih.gov/pubmed/16788244
http://dx.doi.org/10.1155/2006/321798
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