H3N2 canine influenza virus causes severe morbidity in dogs with induction of genes related to inflammation and apoptosis

Dogs are companion animals that live in close proximity with humans. Canine H3N2 influenza virus has been isolated from pet dogs that showed severe respiratory signs and other clinical symptoms such as fever, reduced body weight, and interstitial pneumonia. The canine H3N2 influenza virus can be hig...

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Autores principales: Kang, Young Myong, Kim, Heui Man, Ku, Keun Bon, Park, Eun Hye, Yum, Jung, Seo, Sang Heui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851372/
https://www.ncbi.nlm.nih.gov/pubmed/24090140
http://dx.doi.org/10.1186/1297-9716-44-92
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author Kang, Young Myong
Kim, Heui Man
Ku, Keun Bon
Park, Eun Hye
Yum, Jung
Seo, Sang Heui
author_facet Kang, Young Myong
Kim, Heui Man
Ku, Keun Bon
Park, Eun Hye
Yum, Jung
Seo, Sang Heui
author_sort Kang, Young Myong
collection PubMed
description Dogs are companion animals that live in close proximity with humans. Canine H3N2 influenza virus has been isolated from pet dogs that showed severe respiratory signs and other clinical symptoms such as fever, reduced body weight, and interstitial pneumonia. The canine H3N2 influenza virus can be highly transmissible among dogs via aerosols. When we analyzed global gene expression in the lungs of infected dogs, the genes associated with the immune response and cell death were greatly elevated. Taken together, our results suggest that canine H3N2 influenza virus can be easily transmitted among dogs, and that severe pneumonia in the infected dogs may be partially due to the elevated expression of genes related to inflammation and apoptosis.
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spelling pubmed-38513722013-12-06 H3N2 canine influenza virus causes severe morbidity in dogs with induction of genes related to inflammation and apoptosis Kang, Young Myong Kim, Heui Man Ku, Keun Bon Park, Eun Hye Yum, Jung Seo, Sang Heui Vet Res Research Dogs are companion animals that live in close proximity with humans. Canine H3N2 influenza virus has been isolated from pet dogs that showed severe respiratory signs and other clinical symptoms such as fever, reduced body weight, and interstitial pneumonia. The canine H3N2 influenza virus can be highly transmissible among dogs via aerosols. When we analyzed global gene expression in the lungs of infected dogs, the genes associated with the immune response and cell death were greatly elevated. Taken together, our results suggest that canine H3N2 influenza virus can be easily transmitted among dogs, and that severe pneumonia in the infected dogs may be partially due to the elevated expression of genes related to inflammation and apoptosis. BioMed Central 2013 2013-10-03 /pmc/articles/PMC3851372/ /pubmed/24090140 http://dx.doi.org/10.1186/1297-9716-44-92 Text en Copyright © 2013 Kang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Kang, Young Myong
Kim, Heui Man
Ku, Keun Bon
Park, Eun Hye
Yum, Jung
Seo, Sang Heui
H3N2 canine influenza virus causes severe morbidity in dogs with induction of genes related to inflammation and apoptosis
title H3N2 canine influenza virus causes severe morbidity in dogs with induction of genes related to inflammation and apoptosis
title_full H3N2 canine influenza virus causes severe morbidity in dogs with induction of genes related to inflammation and apoptosis
title_fullStr H3N2 canine influenza virus causes severe morbidity in dogs with induction of genes related to inflammation and apoptosis
title_full_unstemmed H3N2 canine influenza virus causes severe morbidity in dogs with induction of genes related to inflammation and apoptosis
title_short H3N2 canine influenza virus causes severe morbidity in dogs with induction of genes related to inflammation and apoptosis
title_sort h3n2 canine influenza virus causes severe morbidity in dogs with induction of genes related to inflammation and apoptosis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851372/
https://www.ncbi.nlm.nih.gov/pubmed/24090140
http://dx.doi.org/10.1186/1297-9716-44-92
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