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Proteome Analysis—A Novel Approach to Understand the Pathogenesis of Type 1 Diabetes Mellitus
Type 1 (insulin-dependent) diabetes mellitus (T1DM) is associated with a specific destruction of the insulin-producing beta-cells in the islets of Langerhans. Several factors, e.g. genetic, environmental and immunologial, may be involved in the etiology and pathogenesis of T1DM. Autoreactive Tand B-...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2001
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851404/ https://www.ncbi.nlm.nih.gov/pubmed/11790888 http://dx.doi.org/10.1155/2001/202814 |
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author | Karlsen, Allan E. Sparre, Thomas Nielsen, Karin Nerup, Jørn Pociot, Flemming |
author_facet | Karlsen, Allan E. Sparre, Thomas Nielsen, Karin Nerup, Jørn Pociot, Flemming |
author_sort | Karlsen, Allan E. |
collection | PubMed |
description | Type 1 (insulin-dependent) diabetes mellitus (T1DM) is associated with a specific destruction of the insulin-producing beta-cells in the islets of Langerhans. Several factors, e.g. genetic, environmental and immunologial, may be involved in the etiology and pathogenesis of T1DM. Autoreactive Tand B-lymphocytes, together with macrophages infiltrate the islets during the pathogenesis, releasing a mixture of cytokines, demonstrated to be specifically toxic to the beta-cells within the islets. Our goal is to understand the molecular mechanisms responsible for the beta-cell specific toxicity enabling us to design novel intervention strategies in T1DM. The proteome approach allows us to get a detailed picture of the beta-cell proteins, which change expression level or are post-translationally modified in different in vitro and in vivo models of T1DM-associated beta-cell destruction. Combining the information obtained from this extended proteome approach, with that of genetic-, transcriptome- and candidategene approaches, we believe that it is possible to reach this goal. |
format | Online Article Text |
id | pubmed-3851404 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2001 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38514042013-12-22 Proteome Analysis—A Novel Approach to Understand the Pathogenesis of Type 1 Diabetes Mellitus Karlsen, Allan E. Sparre, Thomas Nielsen, Karin Nerup, Jørn Pociot, Flemming Dis Markers Other Type 1 (insulin-dependent) diabetes mellitus (T1DM) is associated with a specific destruction of the insulin-producing beta-cells in the islets of Langerhans. Several factors, e.g. genetic, environmental and immunologial, may be involved in the etiology and pathogenesis of T1DM. Autoreactive Tand B-lymphocytes, together with macrophages infiltrate the islets during the pathogenesis, releasing a mixture of cytokines, demonstrated to be specifically toxic to the beta-cells within the islets. Our goal is to understand the molecular mechanisms responsible for the beta-cell specific toxicity enabling us to design novel intervention strategies in T1DM. The proteome approach allows us to get a detailed picture of the beta-cell proteins, which change expression level or are post-translationally modified in different in vitro and in vivo models of T1DM-associated beta-cell destruction. Combining the information obtained from this extended proteome approach, with that of genetic-, transcriptome- and candidategene approaches, we believe that it is possible to reach this goal. IOS Press 2001 2002-06-07 /pmc/articles/PMC3851404/ /pubmed/11790888 http://dx.doi.org/10.1155/2001/202814 Text en Copyright © 2001 Hindawi Publishing Corporation. |
spellingShingle | Other Karlsen, Allan E. Sparre, Thomas Nielsen, Karin Nerup, Jørn Pociot, Flemming Proteome Analysis—A Novel Approach to Understand the Pathogenesis of Type 1 Diabetes Mellitus |
title | Proteome Analysis—A Novel Approach to Understand the Pathogenesis of Type 1 Diabetes Mellitus |
title_full | Proteome Analysis—A Novel Approach to Understand the Pathogenesis of Type 1 Diabetes Mellitus |
title_fullStr | Proteome Analysis—A Novel Approach to Understand the Pathogenesis of Type 1 Diabetes Mellitus |
title_full_unstemmed | Proteome Analysis—A Novel Approach to Understand the Pathogenesis of Type 1 Diabetes Mellitus |
title_short | Proteome Analysis—A Novel Approach to Understand the Pathogenesis of Type 1 Diabetes Mellitus |
title_sort | proteome analysis—a novel approach to understand the pathogenesis of type 1 diabetes mellitus |
topic | Other |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851404/ https://www.ncbi.nlm.nih.gov/pubmed/11790888 http://dx.doi.org/10.1155/2001/202814 |
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