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Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population
BACKGROUND: Cytogenetic studies in Brazilian population about childhood acute lymphoblastic leukemia (ALL), the most common childhood malignancy, are scarce. Moreover, Brazilian race is very heterogeneous and is made by the confluence of people of several different origins, from the original Native...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851486/ https://www.ncbi.nlm.nih.gov/pubmed/24025689 http://dx.doi.org/10.1186/1755-8166-6-37 |
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author | Gil, Erica Aires Lajus, Tirzah Braz Petta de Moura, Taissa Maria Oliveira Freire, Juliana Mendonça da Fernandes, Andréa Luciana Araújo Leão, Gioconda Dias Rodrigues Nascimento, Edlene Melo Reis do de Alves, Gabriela Vasconcelos Andrade Júnior, Geraldo Barroso Cavalcanti |
author_facet | Gil, Erica Aires Lajus, Tirzah Braz Petta de Moura, Taissa Maria Oliveira Freire, Juliana Mendonça da Fernandes, Andréa Luciana Araújo Leão, Gioconda Dias Rodrigues Nascimento, Edlene Melo Reis do de Alves, Gabriela Vasconcelos Andrade Júnior, Geraldo Barroso Cavalcanti |
author_sort | Gil, Erica Aires |
collection | PubMed |
description | BACKGROUND: Cytogenetic studies in Brazilian population about childhood acute lymphoblastic leukemia (ALL), the most common childhood malignancy, are scarce. Moreover, Brazilian race is very heterogeneous and is made by the confluence of people of several different origins, from the original Native Brazilians, with the influx of Portuguese colonizers, Black African slaves, and recent European, Arab and Japanese immigration. The purpose of this prospective, multicentric study was to assess the sociodemographic, clinic and cytogenetic characteristics of the children treated for ALL in the Northeast region of Brazil. RESULTS: This study includes thirty patients between 4 months and 17 years old treated for ALL from January 1st, 2009 to November 30th, 2010. Cytogenetic analysis showed that in nineteen out of thirty patients (64%) presented some chromosome abnormalities, in which 53% corresponds to numerical abnormalities, 21% structural and numerical abnormalities, and 26% only structural changes. Moreover, seven patients presented complexes karyotype not yet described in the literature. Taken together these results show the importance of the cytogenetic analysis in ALL pediatric patients and illustrates that the studied population presented unexpected complexes karyotypes which were correlated to poor outcome. CONCLUSION: The results demonstrate the importance of banding cytogenetics for ALL diagnosis despite the use of most modern techniques such as FISH and aCGH, and provide reliable insight into the ALL in Brazil. |
format | Online Article Text |
id | pubmed-3851486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-38514862013-12-06 Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population Gil, Erica Aires Lajus, Tirzah Braz Petta de Moura, Taissa Maria Oliveira Freire, Juliana Mendonça da Fernandes, Andréa Luciana Araújo Leão, Gioconda Dias Rodrigues Nascimento, Edlene Melo Reis do de Alves, Gabriela Vasconcelos Andrade Júnior, Geraldo Barroso Cavalcanti Mol Cytogenet Short Report BACKGROUND: Cytogenetic studies in Brazilian population about childhood acute lymphoblastic leukemia (ALL), the most common childhood malignancy, are scarce. Moreover, Brazilian race is very heterogeneous and is made by the confluence of people of several different origins, from the original Native Brazilians, with the influx of Portuguese colonizers, Black African slaves, and recent European, Arab and Japanese immigration. The purpose of this prospective, multicentric study was to assess the sociodemographic, clinic and cytogenetic characteristics of the children treated for ALL in the Northeast region of Brazil. RESULTS: This study includes thirty patients between 4 months and 17 years old treated for ALL from January 1st, 2009 to November 30th, 2010. Cytogenetic analysis showed that in nineteen out of thirty patients (64%) presented some chromosome abnormalities, in which 53% corresponds to numerical abnormalities, 21% structural and numerical abnormalities, and 26% only structural changes. Moreover, seven patients presented complexes karyotype not yet described in the literature. Taken together these results show the importance of the cytogenetic analysis in ALL pediatric patients and illustrates that the studied population presented unexpected complexes karyotypes which were correlated to poor outcome. CONCLUSION: The results demonstrate the importance of banding cytogenetics for ALL diagnosis despite the use of most modern techniques such as FISH and aCGH, and provide reliable insight into the ALL in Brazil. BioMed Central 2013-09-11 /pmc/articles/PMC3851486/ /pubmed/24025689 http://dx.doi.org/10.1186/1755-8166-6-37 Text en Copyright © 2013 Gil et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Gil, Erica Aires Lajus, Tirzah Braz Petta de Moura, Taissa Maria Oliveira Freire, Juliana Mendonça da Fernandes, Andréa Luciana Araújo Leão, Gioconda Dias Rodrigues Nascimento, Edlene Melo Reis do de Alves, Gabriela Vasconcelos Andrade Júnior, Geraldo Barroso Cavalcanti Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population |
title | Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population |
title_full | Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population |
title_fullStr | Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population |
title_full_unstemmed | Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population |
title_short | Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population |
title_sort | banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (all) in a brazilian population |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851486/ https://www.ncbi.nlm.nih.gov/pubmed/24025689 http://dx.doi.org/10.1186/1755-8166-6-37 |
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