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Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population

BACKGROUND: Cytogenetic studies in Brazilian population about childhood acute lymphoblastic leukemia (ALL), the most common childhood malignancy, are scarce. Moreover, Brazilian race is very heterogeneous and is made by the confluence of people of several different origins, from the original Native...

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Autores principales: Gil, Erica Aires, Lajus, Tirzah Braz Petta, de Moura, Taissa Maria Oliveira, Freire, Juliana Mendonça, da Fernandes, Andréa Luciana Araújo, Leão, Gioconda Dias Rodrigues, Nascimento, Edlene Melo Reis do, de Alves, Gabriela Vasconcelos Andrade, Júnior, Geraldo Barroso Cavalcanti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851486/
https://www.ncbi.nlm.nih.gov/pubmed/24025689
http://dx.doi.org/10.1186/1755-8166-6-37
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author Gil, Erica Aires
Lajus, Tirzah Braz Petta
de Moura, Taissa Maria Oliveira
Freire, Juliana Mendonça
da Fernandes, Andréa Luciana Araújo
Leão, Gioconda Dias Rodrigues
Nascimento, Edlene Melo Reis do
de Alves, Gabriela Vasconcelos Andrade
Júnior, Geraldo Barroso Cavalcanti
author_facet Gil, Erica Aires
Lajus, Tirzah Braz Petta
de Moura, Taissa Maria Oliveira
Freire, Juliana Mendonça
da Fernandes, Andréa Luciana Araújo
Leão, Gioconda Dias Rodrigues
Nascimento, Edlene Melo Reis do
de Alves, Gabriela Vasconcelos Andrade
Júnior, Geraldo Barroso Cavalcanti
author_sort Gil, Erica Aires
collection PubMed
description BACKGROUND: Cytogenetic studies in Brazilian population about childhood acute lymphoblastic leukemia (ALL), the most common childhood malignancy, are scarce. Moreover, Brazilian race is very heterogeneous and is made by the confluence of people of several different origins, from the original Native Brazilians, with the influx of Portuguese colonizers, Black African slaves, and recent European, Arab and Japanese immigration. The purpose of this prospective, multicentric study was to assess the sociodemographic, clinic and cytogenetic characteristics of the children treated for ALL in the Northeast region of Brazil. RESULTS: This study includes thirty patients between 4 months and 17 years old treated for ALL from January 1st, 2009 to November 30th, 2010. Cytogenetic analysis showed that in nineteen out of thirty patients (64%) presented some chromosome abnormalities, in which 53% corresponds to numerical abnormalities, 21% structural and numerical abnormalities, and 26% only structural changes. Moreover, seven patients presented complexes karyotype not yet described in the literature. Taken together these results show the importance of the cytogenetic analysis in ALL pediatric patients and illustrates that the studied population presented unexpected complexes karyotypes which were correlated to poor outcome. CONCLUSION: The results demonstrate the importance of banding cytogenetics for ALL diagnosis despite the use of most modern techniques such as FISH and aCGH, and provide reliable insight into the ALL in Brazil.
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spelling pubmed-38514862013-12-06 Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population Gil, Erica Aires Lajus, Tirzah Braz Petta de Moura, Taissa Maria Oliveira Freire, Juliana Mendonça da Fernandes, Andréa Luciana Araújo Leão, Gioconda Dias Rodrigues Nascimento, Edlene Melo Reis do de Alves, Gabriela Vasconcelos Andrade Júnior, Geraldo Barroso Cavalcanti Mol Cytogenet Short Report BACKGROUND: Cytogenetic studies in Brazilian population about childhood acute lymphoblastic leukemia (ALL), the most common childhood malignancy, are scarce. Moreover, Brazilian race is very heterogeneous and is made by the confluence of people of several different origins, from the original Native Brazilians, with the influx of Portuguese colonizers, Black African slaves, and recent European, Arab and Japanese immigration. The purpose of this prospective, multicentric study was to assess the sociodemographic, clinic and cytogenetic characteristics of the children treated for ALL in the Northeast region of Brazil. RESULTS: This study includes thirty patients between 4 months and 17 years old treated for ALL from January 1st, 2009 to November 30th, 2010. Cytogenetic analysis showed that in nineteen out of thirty patients (64%) presented some chromosome abnormalities, in which 53% corresponds to numerical abnormalities, 21% structural and numerical abnormalities, and 26% only structural changes. Moreover, seven patients presented complexes karyotype not yet described in the literature. Taken together these results show the importance of the cytogenetic analysis in ALL pediatric patients and illustrates that the studied population presented unexpected complexes karyotypes which were correlated to poor outcome. CONCLUSION: The results demonstrate the importance of banding cytogenetics for ALL diagnosis despite the use of most modern techniques such as FISH and aCGH, and provide reliable insight into the ALL in Brazil. BioMed Central 2013-09-11 /pmc/articles/PMC3851486/ /pubmed/24025689 http://dx.doi.org/10.1186/1755-8166-6-37 Text en Copyright © 2013 Gil et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Gil, Erica Aires
Lajus, Tirzah Braz Petta
de Moura, Taissa Maria Oliveira
Freire, Juliana Mendonça
da Fernandes, Andréa Luciana Araújo
Leão, Gioconda Dias Rodrigues
Nascimento, Edlene Melo Reis do
de Alves, Gabriela Vasconcelos Andrade
Júnior, Geraldo Barroso Cavalcanti
Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population
title Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population
title_full Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population
title_fullStr Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population
title_full_unstemmed Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population
title_short Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population
title_sort banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (all) in a brazilian population
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851486/
https://www.ncbi.nlm.nih.gov/pubmed/24025689
http://dx.doi.org/10.1186/1755-8166-6-37
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