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The molecular mechanisms on glomangiopericytoma invasion

PURPOSE: To observed the imaging and pathological features of the glomangiopericytoma. EXPERIMENTAL DESIGN: In this paper we report a typical case of glomangiopericytoma arising in the skull base area and summarize the clinical manifestations, imaging and pathological features of such diseases. RESU...

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Detalles Bibliográficos
Autores principales: Sun, Qiang, Zhang, Chunye, Chen, Wantao, He, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851559/
https://www.ncbi.nlm.nih.gov/pubmed/24074285
http://dx.doi.org/10.1186/1750-1172-8-152
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author Sun, Qiang
Zhang, Chunye
Chen, Wantao
He, Yue
author_facet Sun, Qiang
Zhang, Chunye
Chen, Wantao
He, Yue
author_sort Sun, Qiang
collection PubMed
description PURPOSE: To observed the imaging and pathological features of the glomangiopericytoma. EXPERIMENTAL DESIGN: In this paper we report a typical case of glomangiopericytoma arising in the skull base area and summarize the clinical manifestations, imaging and pathological features of such diseases. RESULTS: Immunohistochemical staining confirmed the tumor cells were strongly positive to Vim, SMA, MSA and negative to CD31, CD34. Partial cells were positive to FVIII. The imaging can’t confirm the diagnosis but indicate the the tumor has intact envelope.The cells in the tumor envelope is positive to Vim and negative SMA and FVIII. These findings were compatible with glomangiopericytoma and the cells in the tumor envelope is not glomangiopericytoma cells. CONCLUSION: In view of the clinical and pathological features of the glomangiopericytoma, we believe that the surgery is the best treatment so far and the tumor can be resected completely. The above results can be preliminary reason to explain the low recurrence of such diseases.
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spelling pubmed-38515592013-12-06 The molecular mechanisms on glomangiopericytoma invasion Sun, Qiang Zhang, Chunye Chen, Wantao He, Yue Orphanet J Rare Dis Research PURPOSE: To observed the imaging and pathological features of the glomangiopericytoma. EXPERIMENTAL DESIGN: In this paper we report a typical case of glomangiopericytoma arising in the skull base area and summarize the clinical manifestations, imaging and pathological features of such diseases. RESULTS: Immunohistochemical staining confirmed the tumor cells were strongly positive to Vim, SMA, MSA and negative to CD31, CD34. Partial cells were positive to FVIII. The imaging can’t confirm the diagnosis but indicate the the tumor has intact envelope.The cells in the tumor envelope is positive to Vim and negative SMA and FVIII. These findings were compatible with glomangiopericytoma and the cells in the tumor envelope is not glomangiopericytoma cells. CONCLUSION: In view of the clinical and pathological features of the glomangiopericytoma, we believe that the surgery is the best treatment so far and the tumor can be resected completely. The above results can be preliminary reason to explain the low recurrence of such diseases. BioMed Central 2013-09-29 /pmc/articles/PMC3851559/ /pubmed/24074285 http://dx.doi.org/10.1186/1750-1172-8-152 Text en Copyright © 2013 Sun et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Sun, Qiang
Zhang, Chunye
Chen, Wantao
He, Yue
The molecular mechanisms on glomangiopericytoma invasion
title The molecular mechanisms on glomangiopericytoma invasion
title_full The molecular mechanisms on glomangiopericytoma invasion
title_fullStr The molecular mechanisms on glomangiopericytoma invasion
title_full_unstemmed The molecular mechanisms on glomangiopericytoma invasion
title_short The molecular mechanisms on glomangiopericytoma invasion
title_sort molecular mechanisms on glomangiopericytoma invasion
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851559/
https://www.ncbi.nlm.nih.gov/pubmed/24074285
http://dx.doi.org/10.1186/1750-1172-8-152
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