Evolutionary Adaptation of the Fly Pygo PHD Finger toward Recognizing Histone H3 Tail Methylated at Arginine 2

Pygo proteins promote Armadillo- and β-catenin-dependent transcription, by relieving Groucho-dependent repression of Wnt targets. Their PHD fingers bind histone H3 tail methylated at lysine 4, and to the HD1 domain of their Legless/BCL9 cofactors, linking Pygo to Armadillo/β-catenin. Intriguingly, f...

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Detalles Bibliográficos
Autores principales: Miller, Thomas C.R., Mieszczanek, Juliusz, Sánchez-Barrena, María José, Rutherford, Trevor J., Fiedler, Marc, Bienz, Mariann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851687/
https://www.ncbi.nlm.nih.gov/pubmed/24183574
http://dx.doi.org/10.1016/j.str.2013.09.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851687/
https://www.ncbi.nlm.nih.gov/pubmed/24183574
http://dx.doi.org/10.1016/j.str.2013.09.013

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