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Fatigue in myasthenia gravis: is it more than muscular weakness?

BACKGROUND: Few studies have focused on fatigue in myasthenia gravis (MG), and fatigue in relation to the autonomic system has never been systematically explored in these patients. The study aimed to document the prevalence of MG-related fatigue in ethnic Norwegians and to examine whether MG severit...

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Autores principales: Elsais, Ahmed, Wyller, Vegard B, Loge, Jon Håvard, Kerty, Emilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852076/
https://www.ncbi.nlm.nih.gov/pubmed/24088269
http://dx.doi.org/10.1186/1471-2377-13-132
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author Elsais, Ahmed
Wyller, Vegard B
Loge, Jon Håvard
Kerty, Emilia
author_facet Elsais, Ahmed
Wyller, Vegard B
Loge, Jon Håvard
Kerty, Emilia
author_sort Elsais, Ahmed
collection PubMed
description BACKGROUND: Few studies have focused on fatigue in myasthenia gravis (MG), and fatigue in relation to the autonomic system has never been systematically explored in these patients. The study aimed to document the prevalence of MG-related fatigue in ethnic Norwegians and to examine whether MG severity is associated with symptoms of autonomic disturbance, which in turn is associated with fatigue and functional disability. METHODS: Eighty two of the 97 who fulfilled the study inclusion criteria participated in the study. Controls were 410 age- and sex-matched subjects drawn from a normative sample (n = 2136) representative of the Norwegian population. Bivariate analyses and multivariate linear regression analyses were used to assess associations between questionnaire-reported MG severity, symptoms of autonomic disturbance, fatigue (mental and physical) and functional disability. RESULTS: Forty-four per cent (36/82) of patients fulfilled the criteria for fatigue compared with 22% (90/410) of controls (odds ratio 2.0; p = 0.003). Twenty-one per cent of patients (17/82) met the criteria for chronic fatigue versus 12% (48/410) of controls (odds ratio 1.96; p = 0.03). MG patients had higher total fatigue scores than controls (p < 0.001) and a high prevalence of autonomic symptoms, especially poor thermoregulation and sleep disturbance. According to multivariate analyses controlled for MG score, symptoms of autonomic disturbances were independently positively associated with fatigue (p < 0.001), and fatigue was independently negatively associated with functional level (p < 0.001). CONCLUSION: Norwegian ethnic patients with MG have higher levels of fatigue and a higher prevalence of chronic fatigue than controls, even in patients in full remission. MG severity is highly suggestive to be associated with symptoms of autonomic disturbance, which in turn is associated with fatigue and the level of functional disability.
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spelling pubmed-38520762013-12-06 Fatigue in myasthenia gravis: is it more than muscular weakness? Elsais, Ahmed Wyller, Vegard B Loge, Jon Håvard Kerty, Emilia BMC Neurol Research Article BACKGROUND: Few studies have focused on fatigue in myasthenia gravis (MG), and fatigue in relation to the autonomic system has never been systematically explored in these patients. The study aimed to document the prevalence of MG-related fatigue in ethnic Norwegians and to examine whether MG severity is associated with symptoms of autonomic disturbance, which in turn is associated with fatigue and functional disability. METHODS: Eighty two of the 97 who fulfilled the study inclusion criteria participated in the study. Controls were 410 age- and sex-matched subjects drawn from a normative sample (n = 2136) representative of the Norwegian population. Bivariate analyses and multivariate linear regression analyses were used to assess associations between questionnaire-reported MG severity, symptoms of autonomic disturbance, fatigue (mental and physical) and functional disability. RESULTS: Forty-four per cent (36/82) of patients fulfilled the criteria for fatigue compared with 22% (90/410) of controls (odds ratio 2.0; p = 0.003). Twenty-one per cent of patients (17/82) met the criteria for chronic fatigue versus 12% (48/410) of controls (odds ratio 1.96; p = 0.03). MG patients had higher total fatigue scores than controls (p < 0.001) and a high prevalence of autonomic symptoms, especially poor thermoregulation and sleep disturbance. According to multivariate analyses controlled for MG score, symptoms of autonomic disturbances were independently positively associated with fatigue (p < 0.001), and fatigue was independently negatively associated with functional level (p < 0.001). CONCLUSION: Norwegian ethnic patients with MG have higher levels of fatigue and a higher prevalence of chronic fatigue than controls, even in patients in full remission. MG severity is highly suggestive to be associated with symptoms of autonomic disturbance, which in turn is associated with fatigue and the level of functional disability. BioMed Central 2013-10-03 /pmc/articles/PMC3852076/ /pubmed/24088269 http://dx.doi.org/10.1186/1471-2377-13-132 Text en Copyright © 2013 Elsais et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Elsais, Ahmed
Wyller, Vegard B
Loge, Jon Håvard
Kerty, Emilia
Fatigue in myasthenia gravis: is it more than muscular weakness?
title Fatigue in myasthenia gravis: is it more than muscular weakness?
title_full Fatigue in myasthenia gravis: is it more than muscular weakness?
title_fullStr Fatigue in myasthenia gravis: is it more than muscular weakness?
title_full_unstemmed Fatigue in myasthenia gravis: is it more than muscular weakness?
title_short Fatigue in myasthenia gravis: is it more than muscular weakness?
title_sort fatigue in myasthenia gravis: is it more than muscular weakness?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852076/
https://www.ncbi.nlm.nih.gov/pubmed/24088269
http://dx.doi.org/10.1186/1471-2377-13-132
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