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Effect of Jeju Water on Blood Glucose Levels in Diabetic Patients: A Randomized Controlled Trial

Jeju water is the groundwater of Jeju Island, a volcanic island located in Republic of Korea. We investigated whether Jeju water improved glycemic control in patients with diabetes. This was a 12-week single-center, double-blind, randomized, and controlled trial. The subjects daily drank a liter of...

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Autores principales: Koh, Gwanpyo, Lee, Dae Ho, Lee, Sang Ah, Kang, Eun-Kyung, Hwang, Okkyeong, Han, Hyun-Jung, Kim, Sok Young, Yang, Eun-Jin, Kim, Min-Kyoung, Chin, Hyoun-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852319/
https://www.ncbi.nlm.nih.gov/pubmed/24348692
http://dx.doi.org/10.1155/2013/212918
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author Koh, Gwanpyo
Lee, Dae Ho
Lee, Sang Ah
Kang, Eun-Kyung
Hwang, Okkyeong
Han, Hyun-Jung
Kim, Sok Young
Yang, Eun-Jin
Kim, Min-Kyoung
Chin, Hyoun-Jung
author_facet Koh, Gwanpyo
Lee, Dae Ho
Lee, Sang Ah
Kang, Eun-Kyung
Hwang, Okkyeong
Han, Hyun-Jung
Kim, Sok Young
Yang, Eun-Jin
Kim, Min-Kyoung
Chin, Hyoun-Jung
author_sort Koh, Gwanpyo
collection PubMed
description Jeju water is the groundwater of Jeju Island, a volcanic island located in Republic of Korea. We investigated whether Jeju water improved glycemic control in patients with diabetes. This was a 12-week single-center, double-blind, randomized, and controlled trial. The subjects daily drank a liter of one of three kinds of water: two Jeju waters (S1 and S2) and Seoul tap water (SS). The primary outcome was the proportion of patients in the per-protocol (PP) population achieving glycated hemoglobin (HbA1c) < 7.0% at week 12. In total, 196 patients were randomized and analyzed in the intention-to-treat (ITT) population (66 consuming S1, 63 consuming S2, and 67 consuming SS); 146 patients were considered in the PP population. There were no significant differences in the primary outcomes of the groups consuming S1, S2, or SS. However, the percentage of patients achieving HbA1c < 8% was significantly higher in the S2 group than in the SS group. In the ITT population, the 12-week HbA1c and fructosamine levels were lower in the S1 group than in the SS group and the 4-, 8-, and 12-week fructosamine levels were lower in the S2 group than in the SS group. Although we failed to achieve the primary outcome, it is possible that the Jeju waters improve glycemic control compared with the Seoul tap water in diabetic patients.
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spelling pubmed-38523192013-12-15 Effect of Jeju Water on Blood Glucose Levels in Diabetic Patients: A Randomized Controlled Trial Koh, Gwanpyo Lee, Dae Ho Lee, Sang Ah Kang, Eun-Kyung Hwang, Okkyeong Han, Hyun-Jung Kim, Sok Young Yang, Eun-Jin Kim, Min-Kyoung Chin, Hyoun-Jung Evid Based Complement Alternat Med Research Article Jeju water is the groundwater of Jeju Island, a volcanic island located in Republic of Korea. We investigated whether Jeju water improved glycemic control in patients with diabetes. This was a 12-week single-center, double-blind, randomized, and controlled trial. The subjects daily drank a liter of one of three kinds of water: two Jeju waters (S1 and S2) and Seoul tap water (SS). The primary outcome was the proportion of patients in the per-protocol (PP) population achieving glycated hemoglobin (HbA1c) < 7.0% at week 12. In total, 196 patients were randomized and analyzed in the intention-to-treat (ITT) population (66 consuming S1, 63 consuming S2, and 67 consuming SS); 146 patients were considered in the PP population. There were no significant differences in the primary outcomes of the groups consuming S1, S2, or SS. However, the percentage of patients achieving HbA1c < 8% was significantly higher in the S2 group than in the SS group. In the ITT population, the 12-week HbA1c and fructosamine levels were lower in the S1 group than in the SS group and the 4-, 8-, and 12-week fructosamine levels were lower in the S2 group than in the SS group. Although we failed to achieve the primary outcome, it is possible that the Jeju waters improve glycemic control compared with the Seoul tap water in diabetic patients. Hindawi Publishing Corporation 2013 2013-11-18 /pmc/articles/PMC3852319/ /pubmed/24348692 http://dx.doi.org/10.1155/2013/212918 Text en Copyright © 2013 Gwanpyo Koh et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Koh, Gwanpyo
Lee, Dae Ho
Lee, Sang Ah
Kang, Eun-Kyung
Hwang, Okkyeong
Han, Hyun-Jung
Kim, Sok Young
Yang, Eun-Jin
Kim, Min-Kyoung
Chin, Hyoun-Jung
Effect of Jeju Water on Blood Glucose Levels in Diabetic Patients: A Randomized Controlled Trial
title Effect of Jeju Water on Blood Glucose Levels in Diabetic Patients: A Randomized Controlled Trial
title_full Effect of Jeju Water on Blood Glucose Levels in Diabetic Patients: A Randomized Controlled Trial
title_fullStr Effect of Jeju Water on Blood Glucose Levels in Diabetic Patients: A Randomized Controlled Trial
title_full_unstemmed Effect of Jeju Water on Blood Glucose Levels in Diabetic Patients: A Randomized Controlled Trial
title_short Effect of Jeju Water on Blood Glucose Levels in Diabetic Patients: A Randomized Controlled Trial
title_sort effect of jeju water on blood glucose levels in diabetic patients: a randomized controlled trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852319/
https://www.ncbi.nlm.nih.gov/pubmed/24348692
http://dx.doi.org/10.1155/2013/212918
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