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Micro-osmotic pumps for continuous release of the tyrosine kinase inhibitor bosutinib in juvenile rats and its impact on bone growth

BACKGROUND: Bosutinib is a third-generation dual tyrosine kinase inhibitor (TKI) inhibiting Abl and Src kinases. It was developed to act on up-regulated tyrosine kinases (TKs) like BCR-ABL in Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML) when resistance to first- and second-g...

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Detalles Bibliográficos
Autores principales:	Tauer, Josephine Tabea, Hofbauer, Lorenz C., Jung, Roland, Erben, Reinhold G., Suttorp, Meinolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2013
Materias:	Animal Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852366/ https://www.ncbi.nlm.nih.gov/pubmed/24185529 http://dx.doi.org/10.12659/MSMBR.889518

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