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Mated Progeny Production Is a Biomarker of Aging in Caenorhabditis elegans

The relationships between reproduction and aging are important for understanding the mechanisms of aging and evaluating evolutionary theories of aging. To investigate the effects of progeny production on reproductive and somatic aging, we conducted longitudinal studies of Caenorhabditis elegans herm...

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Autores principales: Pickett, Christopher L., Dietrich, Nicholas, Chen, Junfang, Xiong, Chengjie, Kornfeld, Kerry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852384/
https://www.ncbi.nlm.nih.gov/pubmed/24142929
http://dx.doi.org/10.1534/g3.113.008664
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author Pickett, Christopher L.
Dietrich, Nicholas
Chen, Junfang
Xiong, Chengjie
Kornfeld, Kerry
author_facet Pickett, Christopher L.
Dietrich, Nicholas
Chen, Junfang
Xiong, Chengjie
Kornfeld, Kerry
author_sort Pickett, Christopher L.
collection PubMed
description The relationships between reproduction and aging are important for understanding the mechanisms of aging and evaluating evolutionary theories of aging. To investigate the effects of progeny production on reproductive and somatic aging, we conducted longitudinal studies of Caenorhabditis elegans hermaphrodites. For mated wild-type animals that were not sperm limited and survived past the end of the reproductive period, high levels of cross-progeny production were positively correlated with delayed reproductive and somatic aging. In this group of animals, individuals that generated more cross progeny also reproduced and lived longer than individuals that generated fewer cross progeny. These results indicate that progeny production does not accelerate reproductive or somatic aging. This longitudinal study demonstrated that cumulative cross progeny production through day four is an early-stage biomarker that is a positive predictor of longevity. Furthermore, in mated animals, high levels of early cross progeny production were positively correlated with high levels of late cross progeny production, indicating that early progeny production does not accelerate reproductive aging. The relationships between progeny production and aging were further evaluated by comparing self-fertile hermaphrodites that generated relatively few self progeny with mated hermaphrodites that generated many cross progeny. The timing of age-related somatic degeneration was similar in these groups, suggesting progeny production does not accelerate somatic aging. These studies rigorously define relationships between progeny production, reproductive aging, and somatic aging and identify new biomarkers of C. elegans aging. These results indicate that some mechanisms or pathways control age-related degeneration of both reproductive and somatic tissues in C. elegans.
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spelling pubmed-38523842013-12-06 Mated Progeny Production Is a Biomarker of Aging in Caenorhabditis elegans Pickett, Christopher L. Dietrich, Nicholas Chen, Junfang Xiong, Chengjie Kornfeld, Kerry G3 (Bethesda) Investigations The relationships between reproduction and aging are important for understanding the mechanisms of aging and evaluating evolutionary theories of aging. To investigate the effects of progeny production on reproductive and somatic aging, we conducted longitudinal studies of Caenorhabditis elegans hermaphrodites. For mated wild-type animals that were not sperm limited and survived past the end of the reproductive period, high levels of cross-progeny production were positively correlated with delayed reproductive and somatic aging. In this group of animals, individuals that generated more cross progeny also reproduced and lived longer than individuals that generated fewer cross progeny. These results indicate that progeny production does not accelerate reproductive or somatic aging. This longitudinal study demonstrated that cumulative cross progeny production through day four is an early-stage biomarker that is a positive predictor of longevity. Furthermore, in mated animals, high levels of early cross progeny production were positively correlated with high levels of late cross progeny production, indicating that early progeny production does not accelerate reproductive aging. The relationships between progeny production and aging were further evaluated by comparing self-fertile hermaphrodites that generated relatively few self progeny with mated hermaphrodites that generated many cross progeny. The timing of age-related somatic degeneration was similar in these groups, suggesting progeny production does not accelerate somatic aging. These studies rigorously define relationships between progeny production, reproductive aging, and somatic aging and identify new biomarkers of C. elegans aging. These results indicate that some mechanisms or pathways control age-related degeneration of both reproductive and somatic tissues in C. elegans. Genetics Society of America 2013-10-18 /pmc/articles/PMC3852384/ /pubmed/24142929 http://dx.doi.org/10.1534/g3.113.008664 Text en Copyright © 2013 Pickett et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Investigations
Pickett, Christopher L.
Dietrich, Nicholas
Chen, Junfang
Xiong, Chengjie
Kornfeld, Kerry
Mated Progeny Production Is a Biomarker of Aging in Caenorhabditis elegans
title Mated Progeny Production Is a Biomarker of Aging in Caenorhabditis elegans
title_full Mated Progeny Production Is a Biomarker of Aging in Caenorhabditis elegans
title_fullStr Mated Progeny Production Is a Biomarker of Aging in Caenorhabditis elegans
title_full_unstemmed Mated Progeny Production Is a Biomarker of Aging in Caenorhabditis elegans
title_short Mated Progeny Production Is a Biomarker of Aging in Caenorhabditis elegans
title_sort mated progeny production is a biomarker of aging in caenorhabditis elegans
topic Investigations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852384/
https://www.ncbi.nlm.nih.gov/pubmed/24142929
http://dx.doi.org/10.1534/g3.113.008664
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