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Infliximab-Induced Hypothyroidism: A Novel Case and Postulations concerning the Mechanism

We report a patient with cutaneous sarcoidosis who developed hypothyroidism following 17 months of infliximab therapy. To our knowledge, this is the first reported case of hypothyroidism following infliximab administration. While it is possible that the patient's hypothyroidism was unrelated to...

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Detalles Bibliográficos
Autores principales: Cerniglia, Brett, Judson, Marc A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852574/
https://www.ncbi.nlm.nih.gov/pubmed/24348571
http://dx.doi.org/10.1155/2013/216939
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author Cerniglia, Brett
Judson, Marc A.
author_facet Cerniglia, Brett
Judson, Marc A.
author_sort Cerniglia, Brett
collection PubMed
description We report a patient with cutaneous sarcoidosis who developed hypothyroidism following 17 months of infliximab therapy. To our knowledge, this is the first reported case of hypothyroidism following infliximab administration. While it is possible that the patient's hypothyroidism was unrelated to the use of infliximab, the time course and lack of alternative explanations make such an association plausible. We postulate that hypothyroidism in this patient may have been related to the development of autoantibodies to infliximab that triggered the development of an autoimmune thyroiditis. Regardless of the mechanism, we would encourage clinicians to keep the potential mechanisms of TNF-α in mind when treating patients with TNF-α antagonist medications.
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spelling pubmed-38525742013-12-12 Infliximab-Induced Hypothyroidism: A Novel Case and Postulations concerning the Mechanism Cerniglia, Brett Judson, Marc A. Case Rep Med Case Report We report a patient with cutaneous sarcoidosis who developed hypothyroidism following 17 months of infliximab therapy. To our knowledge, this is the first reported case of hypothyroidism following infliximab administration. While it is possible that the patient's hypothyroidism was unrelated to the use of infliximab, the time course and lack of alternative explanations make such an association plausible. We postulate that hypothyroidism in this patient may have been related to the development of autoantibodies to infliximab that triggered the development of an autoimmune thyroiditis. Regardless of the mechanism, we would encourage clinicians to keep the potential mechanisms of TNF-α in mind when treating patients with TNF-α antagonist medications. Hindawi Publishing Corporation 2013 2013-11-19 /pmc/articles/PMC3852574/ /pubmed/24348571 http://dx.doi.org/10.1155/2013/216939 Text en Copyright © 2013 B. Cerniglia and M. A. Judson. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Cerniglia, Brett
Judson, Marc A.
Infliximab-Induced Hypothyroidism: A Novel Case and Postulations concerning the Mechanism
title Infliximab-Induced Hypothyroidism: A Novel Case and Postulations concerning the Mechanism
title_full Infliximab-Induced Hypothyroidism: A Novel Case and Postulations concerning the Mechanism
title_fullStr Infliximab-Induced Hypothyroidism: A Novel Case and Postulations concerning the Mechanism
title_full_unstemmed Infliximab-Induced Hypothyroidism: A Novel Case and Postulations concerning the Mechanism
title_short Infliximab-Induced Hypothyroidism: A Novel Case and Postulations concerning the Mechanism
title_sort infliximab-induced hypothyroidism: a novel case and postulations concerning the mechanism
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852574/
https://www.ncbi.nlm.nih.gov/pubmed/24348571
http://dx.doi.org/10.1155/2013/216939
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