LigSearch: a knowledge-based web server to identify likely ligands for a protein target

Identifying which ligands might bind to a protein before crystallization trials could provide a significant saving in time and resources. LigSearch, a web server aimed at predicting ligands that might bind to and stabilize a given protein, has been developed. Using a protein sequence and/or structur...

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Detalles Bibliográficos
Autores principales: de Beer, Tjaart A. P., Laskowski, Roman A., Duban, Mark-Eugene, Chan, A. W. Edith, Anderson, Wayne F., Thornton, Janet M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2013
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852652/
https://www.ncbi.nlm.nih.gov/pubmed/24311580
http://dx.doi.org/10.1107/S0907444913022294
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author de Beer, Tjaart A. P.
Laskowski, Roman A.
Duban, Mark-Eugene
Chan, A. W. Edith
Anderson, Wayne F.
Thornton, Janet M.
author_facet de Beer, Tjaart A. P.
Laskowski, Roman A.
Duban, Mark-Eugene
Chan, A. W. Edith
Anderson, Wayne F.
Thornton, Janet M.
author_sort de Beer, Tjaart A. P.
collection PubMed
description Identifying which ligands might bind to a protein before crystallization trials could provide a significant saving in time and resources. LigSearch, a web server aimed at predicting ligands that might bind to and stabilize a given protein, has been developed. Using a protein sequence and/or structure, the system searches against a variety of databases, combining available knowledge, and provides a clustered and ranked output of possible ligands. LigSearch can be accessed at http://www.ebi.ac.uk/thornton-srv/databases/LigSearch.
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spelling pubmed-38526522013-12-12 LigSearch: a knowledge-based web server to identify likely ligands for a protein target de Beer, Tjaart A. P. Laskowski, Roman A. Duban, Mark-Eugene Chan, A. W. Edith Anderson, Wayne F. Thornton, Janet M. Acta Crystallogr D Biol Crystallogr Research Papers Identifying which ligands might bind to a protein before crystallization trials could provide a significant saving in time and resources. LigSearch, a web server aimed at predicting ligands that might bind to and stabilize a given protein, has been developed. Using a protein sequence and/or structure, the system searches against a variety of databases, combining available knowledge, and provides a clustered and ranked output of possible ligands. LigSearch can be accessed at http://www.ebi.ac.uk/thornton-srv/databases/LigSearch. International Union of Crystallography 2013-12-01 2013-11-19 /pmc/articles/PMC3852652/ /pubmed/24311580 http://dx.doi.org/10.1107/S0907444913022294 Text en © de Beer et al. 2013 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Research Papers
de Beer, Tjaart A. P.
Laskowski, Roman A.
Duban, Mark-Eugene
Chan, A. W. Edith
Anderson, Wayne F.
Thornton, Janet M.
LigSearch: a knowledge-based web server to identify likely ligands for a protein target
title LigSearch: a knowledge-based web server to identify likely ligands for a protein target
title_full LigSearch: a knowledge-based web server to identify likely ligands for a protein target
title_fullStr LigSearch: a knowledge-based web server to identify likely ligands for a protein target
title_full_unstemmed LigSearch: a knowledge-based web server to identify likely ligands for a protein target
title_short LigSearch: a knowledge-based web server to identify likely ligands for a protein target
title_sort ligsearch: a knowledge-based web server to identify likely ligands for a protein target
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852652/
https://www.ncbi.nlm.nih.gov/pubmed/24311580
http://dx.doi.org/10.1107/S0907444913022294
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