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Structure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg(2+) cofactor

Apurinic/apyrimidinic endonuclease 1 (APE1) mediates the repair of abasic sites and other DNA lesions and is essential for base-excision repair and strand-break repair pathways. APE1 hydrolyzes the phosphodiester bond at abasic sites, producing 5′-deoxyribose phosphate and the 3′-OH primer needed fo...

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Detalles Bibliográficos
Autores principales:	Manvilla, Brittney A., Pozharski, Edwin, Toth, Eric A., Drohat, Alexander C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2013
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852660/ https://www.ncbi.nlm.nih.gov/pubmed/24311596 http://dx.doi.org/10.1107/S0907444913027042

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