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Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity: A Cross-Sectional Study in Men

The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs) are trapped in subendothelial space of the vascular wall where they are oxidized. Previously, we showed that oxidation is not restricted to the subendothelial location. Myeloperoxidase (MPO), an enzyme secreted by ne...

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Autores principales: Zouaoui Boudjeltia, Karim, Delporte, Cédric, Van Antwerpen, Pierre, Franck, Thierry, Serteyn, Didier, Moguilevsky, Nicole, Raes, Martine, Vanhamme, Luc, Vanhaeverbeek, Michel, Van Meerhaeghe, Alain, Roumeguère, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852806/
https://www.ncbi.nlm.nih.gov/pubmed/24347830
http://dx.doi.org/10.1155/2013/750742
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author Zouaoui Boudjeltia, Karim
Delporte, Cédric
Van Antwerpen, Pierre
Franck, Thierry
Serteyn, Didier
Moguilevsky, Nicole
Raes, Martine
Vanhamme, Luc
Vanhaeverbeek, Michel
Van Meerhaeghe, Alain
Roumeguère, Thierry
author_facet Zouaoui Boudjeltia, Karim
Delporte, Cédric
Van Antwerpen, Pierre
Franck, Thierry
Serteyn, Didier
Moguilevsky, Nicole
Raes, Martine
Vanhamme, Luc
Vanhaeverbeek, Michel
Van Meerhaeghe, Alain
Roumeguère, Thierry
author_sort Zouaoui Boudjeltia, Karim
collection PubMed
description The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs) are trapped in subendothelial space of the vascular wall where they are oxidized. Previously, we showed that oxidation is not restricted to the subendothelial location. Myeloperoxidase (MPO), an enzyme secreted by neutrophils and macrophages, can modify LDL (Mox-LDL) at the surface of endothelial cells. In addition we observed that the activation of the endothelial cells by angiotensin II amplifies this process. We suggested that induction of the NADPH oxidase complex was a major step in the oxidative process. Based on these data, we asked whether there was an independent association, in 121 patients, between NADPH oxidase modulators, such as angiotensin II, adiponectin, and levels of circulating Mox-LDL. Our observations suggest that the combination of blood angiotensin II, MPO activity, and adiponectin explains, at least partially, serum Mox-LDL levels.
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spelling pubmed-38528062013-12-15 Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity: A Cross-Sectional Study in Men Zouaoui Boudjeltia, Karim Delporte, Cédric Van Antwerpen, Pierre Franck, Thierry Serteyn, Didier Moguilevsky, Nicole Raes, Martine Vanhamme, Luc Vanhaeverbeek, Michel Van Meerhaeghe, Alain Roumeguère, Thierry Mediators Inflamm Research Article The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs) are trapped in subendothelial space of the vascular wall where they are oxidized. Previously, we showed that oxidation is not restricted to the subendothelial location. Myeloperoxidase (MPO), an enzyme secreted by neutrophils and macrophages, can modify LDL (Mox-LDL) at the surface of endothelial cells. In addition we observed that the activation of the endothelial cells by angiotensin II amplifies this process. We suggested that induction of the NADPH oxidase complex was a major step in the oxidative process. Based on these data, we asked whether there was an independent association, in 121 patients, between NADPH oxidase modulators, such as angiotensin II, adiponectin, and levels of circulating Mox-LDL. Our observations suggest that the combination of blood angiotensin II, MPO activity, and adiponectin explains, at least partially, serum Mox-LDL levels. Hindawi Publishing Corporation 2013 2013-11-18 /pmc/articles/PMC3852806/ /pubmed/24347830 http://dx.doi.org/10.1155/2013/750742 Text en Copyright © 2013 Karim Zouaoui Boudjeltia et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zouaoui Boudjeltia, Karim
Delporte, Cédric
Van Antwerpen, Pierre
Franck, Thierry
Serteyn, Didier
Moguilevsky, Nicole
Raes, Martine
Vanhamme, Luc
Vanhaeverbeek, Michel
Van Meerhaeghe, Alain
Roumeguère, Thierry
Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity: A Cross-Sectional Study in Men
title Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity: A Cross-Sectional Study in Men
title_full Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity: A Cross-Sectional Study in Men
title_fullStr Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity: A Cross-Sectional Study in Men
title_full_unstemmed Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity: A Cross-Sectional Study in Men
title_short Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity: A Cross-Sectional Study in Men
title_sort myeloperoxidase-dependent ldl modifications in bloodstream are mainly predicted by angiotensin ii, adiponectin, and myeloperoxidase activity: a cross-sectional study in men
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852806/
https://www.ncbi.nlm.nih.gov/pubmed/24347830
http://dx.doi.org/10.1155/2013/750742
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