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Synthesis, characterization, and evaluation of a novel inhibitor of WNT/β-catenin signaling pathway

BACKGROUND: Wnt/β-catenin signaling is a highly conserved pathway in organism evolution and is important in many biological processes. Overactivation of Wnt/β-catenin signaling is closely related to tumor development and progression. To identify potent small molecules that can fight aberrant Wnt/β-c...

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Detalles Bibliográficos
Autores principales: Yan, Zhao, Zhu, Zhongling, Wang, Jinghui, Sun, Jian, Chen, Yihui, Yang, Guang, Chen, Wenting, Deng, Yuheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852836/
https://www.ncbi.nlm.nih.gov/pubmed/24098916
http://dx.doi.org/10.1186/1476-4598-12-116