Novel fusion of GLP-1 with a domain antibody to serum albumin prolongs protection against myocardial ischemia/reperfusion injury in the rat

BACKGROUND: Glucagon-like peptide-1 (GLP-1) and its mimetics reduce infarct size in the setting of acute myocardial ischemia/reperfusion (I/R) injury. However, the short serum half-life of GLP-1 and its mimetics may limit their therapeutic use in acute myocardial ischemia. Domain antibodies to serum...

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Detalles Bibliográficos
Autores principales: Bao, Weike, Holt, Lucy J, Prince, Rob D, Jones, Gavin X, Aravindhan, Karpagam, Szapacs, Mathew, Barbour, April M, Jolivette, Larry J, Lepore, John J, Willette, Robert N, DeAngelis, Elena, Jucker, Beat M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852957/
https://www.ncbi.nlm.nih.gov/pubmed/24125539
http://dx.doi.org/10.1186/1475-2840-12-148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852957/
https://www.ncbi.nlm.nih.gov/pubmed/24125539
http://dx.doi.org/10.1186/1475-2840-12-148

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