Cargando…

The Sec63p J-Domain Is Required for ERAD of Soluble Proteins in Yeast

How misfolded proteins are exported from the ER to the cytosol for degradation (ER-associated Degradation, ERAD) and which proteins are participating in this process is not understood. Several studies using a single, leaky mutant indicated that Sec63p might be involved in ERAD. More recently, Sec63p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Servas, Christina, Römisch, Karin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852996/ https://www.ncbi.nlm.nih.gov/pubmed/24324744 http://dx.doi.org/10.1371/journal.pone.0082058

Ejemplares similares

How does Sec63 affect the conformation of Sec61 in yeast?
por: Bhadra, Pratiti, et al.
Publicado: (2021)

The N-terminus of Sec61p plays key roles in ER protein import and ERAD
por: Elia, Francesco, et al.
Publicado: (2019)

Proteasome 19S RP Binding to the Sec61 Channel Plays a Key Role in ERAD
por: Kaiser, Marie-Luise, et al.
Publicado: (2015)

A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome
Publicado: (1993)

ERAD and protein import defects in a sec61 mutant lacking ER-lumenal loop 7
por: Tretter, Thomas, et al.
Publicado: (2013)

Sec61p Is Required for ERAD-L: GENETIC DISSECTION OF THE TRANSLOCATION AND ERAD-L FUNCTIONS OF Sec61P USING NOVEL DERIVATIVES OF CPY
por: Willer, Martin, et al.
Publicado: (2008)

Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62
por: Itskanov, Samuel, et al.
Publicado: (2021)

Analysis of Sec61p and Ssh1p interactions in the ER membrane using the split-ubiquitin system
por: Harty, Carol, et al.
Publicado: (2013)

Interaction between BiP and Sec63p is required for the completion of protein translocation into the ER of Saccharomyces cerevisiae
Publicado: (1995)

Sec34p, a Protein Required for Vesicle Tethering to the Yeast Golgi Apparatus, Is in a Complex with Sec35p
por: VanRheenen, Susan M., et al.
Publicado: (1999)

Emerging View on the Molecular Functions of Sec62 and Sec63 in Protein Translocation
por: Jung, Sung-jun, et al.
Publicado: (2021)

Let’s talk about Secs: Sec61, Sec62 and Sec63 in signal transduction, oncology and personalized medicine
por: Linxweiler, Maximilian, et al.
Publicado: (2017)

Characterization of a gene product (Sec53p) required for protein assembly in the yeast endoplasmic reticulum
Publicado: (1985)

Brr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase
por: Cordin, Olivier, et al.
Publicado: (2014)

The Lumenal Domain of Sec63p Stimulates the ATPase Activity of BiP and Mediates BiP Recruitment to the Translocon in Saccharomyces cerevisiae
por: Corsi, Ann K., et al.
Publicado: (1997)

Role of Human Sec63 in Modulating the Steady-State Levels of Multi-Spanning Membrane Proteins
por: Mades, Andreas, et al.
Publicado: (2012)

Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p
Publicado: (1995)

N-acetylation and phosphorylation of Sec complex subunits in the ER membrane
por: Soromani, Christina, et al.
Publicado: (2012)

A membrane glycoprotein, Sec12p, required for protein transport from the endoplasmic reticulum to the Golgi apparatus in yeast
Publicado: (1988)

SEC11 is required for signal peptide processing and yeast cell growth
Publicado: (1988)

SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum
Publicado: (1989)

Sec61 channel subunit Sbh1/Sec61β promotes ER translocation of proteins with suboptimal targeting sequences and is fine-tuned by phosphorylation
por: Barbieri, Guido, et al.
Publicado: (2023)

Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation
por: Pereira, Fabio, et al.
Publicado: (2019)

The Sec15 protein responds to the function of the GTP binding protein, Sec4, to control vesicular traffic in yeast
Publicado: (1989)

The alpha/beta carboxyterminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins
por: Wolff, Sonja, et al.
Publicado: (2009)

A Sec14 domain protein is required for photoautotrophic growth and chloroplast vesicle formation in Arabidopsis thaliana
por: Hertle, Alexander P., et al.
Publicado: (2020)

Mutation of sec63 in zebrafish causes defects in myelinated axons and liver pathology
por: Monk, Kelly R., et al.
Publicado: (2013)

Loss of Heterozygosity Is Present in SEC63 Germline Carriers with Polycystic Liver Disease
por: Janssen, Manoe J., et al.
Publicado: (2012)

microRNA-1 Regulates NCC Migration and Differentiation by Targeting sec63
por: Wang, Dongyue, et al.
Publicado: (2019)

ERAD of proteins containing aberrant transmembrane domains requires ubiquitylation of cytoplasmic lysine residues
por: Briant, Kit, et al.
Publicado: (2015)

Post-Golgi Sec Proteins Are Required for Autophagy in Saccharomyces cerevisiae
por: Geng, Jiefei, et al.
Publicado: (2010)

Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeast
por: Ortiz, Darinel, et al.
Publicado: (2002)

Structure and Kinetic Stability of the p63 Tetramerization Domain
por: Natan, Eviatar, et al.
Publicado: (2012)

The Saccharomyces cerevisiae SEC14 gene encodes a cytosolic factor that is required for transport of secretory proteins from the yeast Golgi complex
Publicado: (1989)

The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins
por: Suvorova, Elena S., et al.
Publicado: (2002)

Sec35p, a Novel Peripheral Membrane Protein, Is Required for ER to Golgi Vesicle Docking
por: VanRheenen, Susan M., et al.
Publicado: (1998)

Large Deletions in GANAB and SEC63 Explain 2 Cases of Polycystic Kidney and Liver Disease
por: Wilson, Elena M., et al.
Publicado: (2020)

SED4 encodes a yeast endoplasmic reticulum protein that binds Sec16p and participates in vesicle formation
Publicado: (1995)

Evolutionary Gain of Function for the ER Membrane Protein Sec62 from Yeast to Humans
por: Müller, Linda, et al.
Publicado: (2010)

Phosphorylation Provides a Negative Mode of Regulation for the Yeast Rab GTPase Sec4p
por: Heger, Christopher D., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_vvdm3cvp1oo4rug18u9a06821t