Combined TIM-3 blockade and CD137 activation affords the long-term protection in a murine model of ovarian cancer

BACKGROUND: T-cell immunoglobulin and mucin domain 3 (TIM-3) is known as a negative immune regulator and emerging data have implicated TIM-3 a pivotal role in suppressing antitumor immunity. The co-stimulatory receptor CD137 is transiently upregulated on T-cells following activation and increases th...

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Detalles Bibliográficos
Autores principales: Guo, Zhiqiang, Cheng, Dali, Xia, Zhijun, Luan, Meng, Wu, Liangliang, Wang, Gang, Zhang, Shulan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853027/
https://www.ncbi.nlm.nih.gov/pubmed/24044888
http://dx.doi.org/10.1186/1479-5876-11-215

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