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Structural analysis on mutation residues and interfacial water molecules for human TIM disease understanding

BACKGROUND: Human triosephosphate isomerase (HsTIM) deficiency is a genetic disease caused often by the pathogenic mutation E104D. This mutation, located at the side of an abnormally large cluster of water in the inter-subunit interface, reduces the thermostability of the enzyme. Why and how these w...

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Detalles Bibliográficos
Autores principales:	Li, Zhenhua, He, Ying, Liu, Qian, Zhao, Liang, Wong, Limsoon, Kwoh, Chee Keong, Nguyen, Hung, Li, Jinyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853089/ https://www.ncbi.nlm.nih.gov/pubmed/24564410 http://dx.doi.org/10.1186/1471-2105-14-S16-S11

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