Meclizine Inhibits Mitochondrial Respiration through Direct Targeting of Cytosolic Phosphoethanolamine Metabolism

We recently identified meclizine, an over-the-counter drug, as an inhibitor of mitochondrial respiration. Curiously, meclizine blunted respiration in intact cells but not in isolated mitochondria, suggesting an unorthodox mechanism. Using a metabolic profiling approach, we now show that treatment wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Gohil, Vishal M., Zhu, Lin, Baker, Charli D., Cracan, Valentin, Yaseen, Abbas, Jain, Mohit, Clish, Clary B., Brookes, Paul S., Bakovic, Marica, Mootha, Vamsi K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Bioenergetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853286/
https://www.ncbi.nlm.nih.gov/pubmed/24142790
http://dx.doi.org/10.1074/jbc.M113.489237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853286/
https://www.ncbi.nlm.nih.gov/pubmed/24142790
http://dx.doi.org/10.1074/jbc.M113.489237

Ejemplares similares